ArticleScientific reports2019
TSA restores hair follicle-inductive capacity of skin-derived precursors.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Advances in engineered organoid models of skin for biomedical research.Burns & trauma · 2025Review
- Tissue Engineering-Based Strategies for Diabetic Foot Ulcer Management.Advances in wound care · 2023Review
- The dermal papilla dilemma and potential breakthroughs in bioengineering hair follicles.Cell and tissue research · 2023Review
- Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration.Regenerative therapy · 2022Review
- Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review.Life (Basel, Switzerland) · 2022Review
- The Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation.Chonnam medical journal · 2022Review
- Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells.Scientific reports · 2021Article
- Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis.The EMBO journal · 2021Review
- Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia-A Review.Biomedicines · 2021Review
- Article
- Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration.Materials today. Bio · 2021Review
- Functional hair follicle regeneration: an updated review.Signal transduction and targeted therapy · 2021Review
- Glucose metabolism regulates expression of hair-inductive genes of dermal papilla spheres via histone acetylation.Scientific reports · 2020Article
- Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?Stem cells translational medicine · 2020Article
- Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the GIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
The genesis of the hair follicle relies on signals derived from mesenchymal cells in the dermis during skin morphogenesis and regeneration. Multipotent skin-derived precursors (SKPs), which exhibit long term proliferation potential when being cultured in spheroids, have been shown to induce hair genesis and hair follicle regeneration in mice, implying a therapeutic potential of SKPs in hair follicle regeneration and bioengineering. However, the hair-inductive property of SKPs declines progressively upon ex vivo culture expansion, suggesting that the expressions of the genes responsible for hair induction are epigenetically unstable. In this study, we found that TSA markedly alleviated culture expansion induced SKP senescence, increased the expression and activity of alkaline phosphatase (AP) in the cells and importantly restored the hair inductive capacity of SKPs. TSA increased the acetylation level of histone H3, including the K19/14 sites in the promoter regions of bone morphogenetic proteins (BMPs) genes, which were associated with elevated gene expression and BMP signaling activity, suggesting a potential attribution of BMP pathway in TSA induced recovery of the hair inductive capacity of SKPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.