ArticleScientific reports2019
(p)ppGpp-mediated stress response induced by defects in outer membrane biogenesis and ATP production promotes survival in Escherichia coli.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 41 citations in OpenAlex.
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- Peptidoglycan Remodeling in Gram-Negative Bacteria: From Stress Adaptation to Antibiotic Tolerance and Therapeutic Targeting.Antibiotics (Basel, Switzerland) · 2026Review
- The (p)ppGpp Synthetase RelA Contributes to Virulence, Competition Capability and Antibiotic Resistance of Avian PathogenicMicroorganisms · 2026Article
- A phosphohistidine phosphatase promotes starvation survival by dephosphorylating nucleoside diphosphate kinase.Cell reports · 2026Article
- Bactericidal Activity of Selenium Nanoparticles Against a Multidrug-Resistant Pathogen: Mechanistic Hypothesis from Exploratory Proteomics.Microorganisms · 2025Article
- Medium dependent factors govern the functionality of engineered type III secretion systems.Journal of biological engineering · 2025Article
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- Regulation of the transcription factor CdnL promotes adaptation to nutrient stress inPNAS nexus · 2024Article
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- Lipopolysaccharide transport regulates bacterial sensitivity to a cell wall-degrading intermicrobial toxin.PLoS pathogens · 2023Article
- Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin.bioRxiv : the preprint server for biology · 2023Article
- Membrane Proteins as a Regulator for Antibiotic Persistence in Gram-Negative Bacteria.Journal of microbiology (Seoul, Korea) · 2023Review
- (p)ppGpp and moonlighting RNases influence the first step of lipopolysaccharide biosynthesis inmicroLife · 2023Article
- Revealing novel synergistic defense and acid tolerant performance of Escherichia coli in response to organic acid stimulation.Applied microbiology and biotechnology · 2022Article
- Intercellular interaction mechanisms promote diversity in intracellular ATP concentration in Escherichia coli populations.Scientific reports · 2022Article
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- Transcriptomic profiling of Escherichia coli K-12 in response to a compendium of stressors.Scientific reports · 2022Article
- Protein domain-dependent vesiculation of Lipoprotein A, a protein that is important in cell wall synthesis and fitness of the human respiratory pathogenFrontiers in cellular and infection microbiology · 2022Article
- Mutations inFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular growth requires a high level of coordination to ensure that all processes run in concert. The role of the nucleotide alarmone (p)ppGpp has been extensively studied in response to external stresses, such as amino acid starvation, in Escherichia coli, but much less is known about the involvement of (p)ppGpp in response to perturbations in intracellular processes. We therefore employed CRISPRi to transcriptionally repress essential genes involved in 14 vital processes and investigated whether a (p)ppGpp-mediated response would be induced. We show that (p)ppGpp is produced and required for a pertinent stress response during interference with outer membrane biogenesis and ADP synthesis specifically. When these processes were perturbed via the transcriptional repression of essential genes, wild type E. coli MG1655 ceased growing and entered a semi-dormant state, whereas isogenic (p)ppGpp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.