Evidence map›Paper›PMID 30814528›Full record

ArticleScientific reports2019

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry.

Klára Ščupáková, Vasilis Terzopoulos, Saurabh Jain, Dirk Smeets, Ron M A Heeren

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Emerging Computational Methods in Mass Spectrometry Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Klára ŠčupákováMaastricht MultiModal Molecular Imaging institute (M4I), Maastricht, 6229 ER, The Netherlands. k.scupakova@maastrichtuniversity.nl.ORCID 0000-0002-9726-3565
Vasilis TerzopoulosIcometrix, R&D, Leuven, 3000, Belgium.
Saurabh JainIcometrix, R&D, Leuven, 3000, Belgium.
Dirk SmeetsIcometrix, R&D, Leuven, 3000, Belgium.
Ron M A HeerenMaastricht MultiModal Molecular Imaging institute (M4I), Maastricht, 6229 ER, The Netherlands. r.heeren@maastrichtuniversity.nl.ORCID 0000-0002-6533-7179

Funding

Hypoxia-derived molecular MSI signatures to predict breast cancer outcomeR01CA213492 · NCI · JOHNS HOPKINS UNIVERSITY · PI GLUNDE, KRISTINE, HEEREN, RON · 2017 to 2021
$2.1M
NCI NIH HHS R01 CA213492
6 · The paper itself

Abstract

Mass spectrometry imaging (MSI) and histology are complementary analytical tools. Integration of the two imaging modalities can enhance the spatial resolution of the MSI beyond its experimental limits. Patch-based super resolution (PBSR) is a method where high spatial resolution features from one image modality guide the reconstruction of a low resolution image from a second modality. The principle of PBSR lies in image redundancy and aims at finding similar pixels in the neighborhood of a central pixel that are then used to guide reconstruction of the central pixel. In this work, we employed PBSR to increase the resolution of MSI. We validated the proposed pipeline by using a phantom image (micro-dissected logo within a tissue) and mouse cerebellum samples. We compared the performance of the PBSR with other well-known methods: linear interpolation (LI) and image fusion (IF). Quantitative and qualitative assessment showed advantage over the former and comparability with the latter. Furthermore, we demonstrated the potential applicability of PBSR in a clinical setting by accurately integrating structural (i.e., histological) and molecular (i.e., MSI) information from a case study of a dog liver.

Indexed as

AlgorithmsAnimalsCerebellumClinical Laboratory TechniquesDiagnostic ImagingDogsHumansImage EnhancementLiverMass SpectrometryMicePhantoms, Imaging

Identifiers

PMID30814528
PMCPMC6393664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.