ArticleNature communications2019
Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis.
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In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- SLC1A5 prevents aortic aneurysm and dissection by glutaminolytic-epigenetic orchestration of vascular smooth muscle cell homeostasis.Nature communications · 2026Article
- Sex-specific angiogenic responses in endothelial cells-role of the pluripotency factor OCT4.Angiogenesis · 2025Article
- Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells.American journal of human genetics · 2025Article
- Kindlin-2 Deletion in Mural Cells Leads to Vascular Instability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort.Biomedicines · 2025Article
- Pericytes require physiological oxygen tension to maintain phenotypic fidelity.Scientific reports · 2024Article
- Role of N6-methyladenosine in tumor neovascularization.Cell death & disease · 2024Review
- Vascular Smooth Muscle Cells Transdifferentiate into Chondrocyte-Like Cells and Facilitate Meniscal Fibrocartilage Regeneration.Research (Washington, D.C.) · 2024Article
- "Cre"ating New Tools for Smooth Muscle Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- A New AutosomalArteriosclerosis, thrombosis, and vascular biology · 2023Article
- Correlation between stem cell molecular phenotype and atherosclerotic plaque neointima formation and analysis of stem cell signal pathways.Frontiers in cell and developmental biology · 2023Review
- Expression ofFrontiers in oncology · 2023Article
- Smooth muscle cells-specific loss of OCT4 accelerates neointima formation after acute vascular injury.Frontiers in cardiovascular medicine · 2023Article
- Generation and Comparative Analysis of anNature cardiovascular research · 2022Article
- Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction.Cardiovascular research · 2022Article
- Role of Semaphorins in Ischemic Stroke.Frontiers in molecular neuroscience · 2022Review
- SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.Circulation research · 2021Article
- OCT4-mediated inflammation induces cell reprogramming at the origin of cardiac valve development and calcification.Science advances · 2021Article
- Oct4-dependent FoxC1 activation improves the survival and neovascularization of mesenchymal stem cells under myocardial ischemia.Stem cell research & therapy · 2021Article
- Angiogenesis as a hallmark of solid tumors - clinical perspectives.Cellular oncology (Dordrecht, Netherlands) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Daniel L HessRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA.
Molly R Kelly-GossRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA.
Olga A CherepanovaLerner Research Institute, 9500 Euclid Avenue, NB50, Cleveland, OH, 44195, USA.
Anh T NguyenRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA.
Richard A BaylisRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0001-7040-7920
Svyatoslav TkachenkoLerner Research Institute, 9500 Euclid Avenue, JJN3-01, Cleveland, OH, 44195, USA.
Brian H AnnexRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA.
Shayn M PeirceRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA.
Gary K OwensRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, 415 Lane Road, Suite 1010, Charlottesville, VA, 22908, USA. gko@virginia.edu.
University of Virginia · US
Funding
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4MEpigenetic Control of Smooth Muscle Cell Lineage and Phenotypic SwitchingR01HL057353 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2008 to 2016
$3.5MEndothelial Cell to Mesenchymal Cell Transitions Play a Critical Biological Sex- and Aging-Dependent Role in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous CapR01HL156849 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2022 to 2025
$3.2MIL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1MOct4 and Klf4 regulate microvascular SMC-pericyte plasticity, angiogenesis, and metabolic dysfunctionR01HL135018 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$3.1MDefining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0MThe Anti-angiogenic VEGF165b and VEGFR1 Signaling in Peripheral Artery DiseaseR01HL141325 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H · 2019 to 2022
$2.7MPDGFbeta Receptor Activation Promotes Atheroprotective Changes in SMC PhenotypeR01HL132904 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$2.6MAdipose Stem Cells for Diabetic RetinopathyR01EY022063 · NEI · UNIVERSITY OF VIRGINIA · PI HERMAN, IRA M, PEIRCE-COTTLER, SHAYN · 2012 to 2015
$2.0MArteriole/Venule Polarity in Adult MicrovasculatureR01HL082838 · NHLBI · UNIVERSITY OF VIRGINIA · PI PEIRCE-COTTLER, SHAYN · 2007 to 2011
$1.9MNHLBI NIH HHS R01 HL132904NHLBI NIH HHS R01 HL135018NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL141325NHLBI NIH HHS R01 HL141425NHLBI NIH HHS R01 HL156849NIGMS NIH HHS T32 GM007267NIH HHS 1R01 HL116455NIH HHS 1R01 HL12635NIH HHS 2R01 HL101200NIH HHS R01 EY022063NIH HHS R01 HL057353NIH HHS R01 HL082838NIH HHS R01 HL135018NIH HHS T32 HL007284
Abstract
The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC) investment. Here, we show using Myh11-CreER
Indexed as
Neovascularization, PhysiologicAnimalsCell DeathCell LineageCell MovementCells, CulturedCorneal NeovascularizationFemaleHindlimbIschemiaMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleMembrane ProteinsOctamer Transcription Factor-3Pou5f1 protein, mouseSlit3 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.