ReviewNeurologia medico-chirurgica2019
Changing the Currently Held Concept of Cerebrospinal Fluid Dynamics Based on Shared Findings of Cerebrospinal Fluid Motion in the Cranial Cavity Using Various Types of Magnetic Resonance Imaging Techniques.
Review in Neurologia medico-chirurgica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Brain Pulsation Imaging Using Non-Balanced Steady-State Free Precession With 3D-EPI Readout.Magnetic resonance in medicine · 2026Article
- Imaging the therapeutic effects of cerebral endothelial cell derived exosome treatment of a preclinical model of Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Ultrafast Imaging of Physiological Brain Pulsations With Magnetic Resonance Encephalography-From Noise to Predictive Clinical Biomarker.NMR in biomedicine · 2025Review
- Evaluating amplified magnetic resonance imaging as an input for computational fluid dynamics models of the cerebrospinal fluid.Interface focus · 2025Article
- Initiation of transthyretin aggregation at neutral pH by fluid agitation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.Fluids and barriers of the CNS · 2025Review
- Aggregation of Transthyretin by Fluid Agitation.bioRxiv : the preprint server for biology · 2024Article
- The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases.Brain sciences · 2024Review
- Which Theory of Cerebrospinal Fluid Production and Absorption Do Neurosurgeons Teach to Medical Students? Survey from Medical Universities in Japan, 2022.Neurologia medico-chirurgica · 2024Article
- Review
- Dynamic asymmetry in cerebrospinal fluid pressure: An indicator of regional differences in compliance.Surgical neurology international · 2023Article
- Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.Fluids and barriers of the CNS · 2022Review
- Article
- Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Evaluation of Cardiac- and Respiratory-driven Cerebrospinal Fluid Motions by Applying the S-transform to Steady-state Free Precession Phase Contrast Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Review
- An Alzheimer's Disease Mechanism Based on Early Pathology, Anatomy, Vascular-Induced Flow, and Migration of Maximum Flow Stress Energy Location with Increasing Vascular Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Computational fluid dynamics model to predict the dynamical behavior of the cerebrospinal fluid through implementation of physiological boundary conditions.Frontiers in bioengineering and biotechnology · 2022Article
- Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "cerebrospinal fluid (CSF) circulation theory" of CSF flowing unidirectionally and circulating through the ventricles and subarachnoid space in a downward or upward fashion has been widely recognized. In this review, observations of CSF motion using different magnetic resonance imaging (MRI) techniques are described, findings that are shared among these techniques are extracted, and CSF motion, as we currently understand it based on the results from the quantitative analysis of CSF motion, is discussed, along with a discussion of slower water molecule motion in the perivascular, paravascular, and brain parenchyma. Today, a shared consensus regarding CSF motion is being formed, as follows: CSF motion is not a circulatory flow, but a combination of various directions of flow in the ventricles and subarachnoid space, and the acceleration of CSF motion differs depending on the CSF space. It is now necessary to revise the currently held concept that CSF flows unidirectionally. Currently, water molecule motion in the order of centimeters per second can be detected with various MRI techniques. Thus, we need new MRI techniques with high-velocity sensitivity, such as in the order of 10 μm/s, to determine water molecule movement in the vessel wall, paravascular space, and brain parenchyma. In this paper, the authors review the previous and current concepts of CSF motion in the central nervous system using various MRI techniques.
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