Evidence map›Paper›PMID 30814334›Full record

ArticleJournal of cell science2019

Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling.

Gabriella M Forte, Elizabeth Davie, Shervi Lie, Mirita Franz-Wachtel, Ashley J Ovens, Tingting Wang, Jonathan S Oakhill, Boris Maček, Iain M Hagan, Janni Petersen

Open access · hybridAbstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Gabriella M ForteFaculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
Elizabeth DavieFaculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.ORCID 0000-0003-3784-8374
Shervi LieFlinders Centre for Innovation in Cancer, College of Medicine & Public health, Flinders University, Adelaide, SA 5001, Australia.
Mirita Franz-WachtelProteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
Ashley J OvensMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Victoria 3065, Australia.
Tingting WangFlinders Centre for Innovation in Cancer, College of Medicine & Public health, Flinders University, Adelaide, SA 5001, Australia.
Jonathan S OakhillMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Victoria 3065, Australia.
Boris MačekProteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
Iain M HaganCancer Research UK Manchester institute, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Janni PetersenFaculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom janni.petersen@flinders.edu.au.ORCID 0000-0003-0729-9335
Flinders University · AUThe University of Melbourne · AUUniversity of Manchester · GBUniversity of Tübingen · DECancer Research UK Manchester Institute · GB

Funding

Cancer Research UK 16406Cancer Research UK 24458Cancer Research UK C10888/A11178Worldwide Cancer Research 16-0052
6 · The paper itself

Abstract

AMP-activated kinase (AMPK) and target of rapamycin (TOR) signalling coordinate cell growth, proliferation, metabolism and cell survival with the nutrient environment of cells. The poor vasculature and nutritional stress experienced by cells in solid tumours raises the question: how do they assimilate sufficient nutrients to survive? Here, we show that human and fission yeast cells import ATP and AMP from their external environment to regulate AMPK and TOR signalling. Exposure of fission yeast (

Indexed as

Signal TransductionAdenosine TriphosphateAMP-Activated Protein KinasesCell ProliferationConnexinsGene Expression Regulation, FungalHEK293 CellsHumansMechanistic Target of Rapamycin Complex 1Nerve Tissue ProteinsPhosphorylationSchizosaccharomycesSchizosaccharomyces pombe ProteinsStress, PhysiologicalAdenosine TriphosphateAMP-Activated Protein KinasesConnexinsMechanistic Target of Rapamycin Complex 1Nerve Tissue ProteinsPANX1 protein, humanSchizosaccharomyces pombe ProteinsAMPAMPKATPFission yeastNutrient stressSchizosaccharomyces pombeSsp2TORC1Tsc1Tsc2

Identifiers

PMID30814334
PMCPMC6467490
OpenAlexW2915845564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.