Observational studyNeurology2019
Perivascular spaces contribute to cognition beyond other small vessel disease markers.
Abstract readObservational Study
In one paragraph
Observational study in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
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61citing papers in PubMed, 3 pooled it
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The trial behind it
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Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of the relationship between the number and location of perivascular spaces in the brain and cognitive function.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- The Relationship Between Enlarged Perivascular Spaces and Cognitive Function: A Meta-Analysis of Observational Studies.Frontiers in pharmacology · 2020Pooled it
- Research trend of functional magnetic resonance imaging in diabetes mellitus research: a visualization and bibliometric analysis.Frontiers in neurologyPooled it
- Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence.Biological psychiatry global open science · 2026Article
- DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study.Human brain mapping · 2026Article
- Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years.Stroke · 2026Article
- Association of MRI-Visible Perivascular Spaces With Longitudinal Cognitive Decline Over a Decade.Neurology · 2026Observational
- Prognostic value of magnetic resonance imaging-visible perivascular spaces in patients with idiopathic normal pressure hydrocephalus.Quantitative imaging in medicine and surgery · 2026Article
- Aortic Stiffness and Alzheimer's Disease: The Medin Connection.Biomolecules · 2025Review
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging.npj aging · 2025Article
- Does Obstructive sleep apnea mediate the risk of cognitive impairment by expanding the perivascular space?Sleep & breathing = Schlaf & Atmung · 2025Article
- Cerebral Small Vessel Disease is Associated with Prehospital Delay in Acute Ischemic Stroke.Journal of atherosclerosis and thrombosis · 2025Article
- Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Enlarged perivascular space burden predicts declines in cognitive and functional performance.Journal of the neurological sciences · 2024Article
- Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson's disease.Journal of neurology · 2024Article
- Perivascular space burden interacts with APOE-ε4 status on cognition in older adults.Neurobiology of aging · 2024Article
- Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclincal models.American journal of physiology. Heart and circulatory physiology · 2024Review
- Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease.Aging and disease · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Brittany S PassiakFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Dandan LiuFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Hailey A KresgeFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Francis E CambroneroFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Kimberly R PechmanFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Katie E OsbornFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Katherine A GiffordFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Timothy J HohmanFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Matthew S SchragFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
L Taylor DavisFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN.
Angela L JeffersonFrom the Vanderbilt Memory & Alzheimer's Center (B.S.P., D.L., H.A.K., F.E.C., K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Neurology (K.R.P., K.E.O., K.A.G., T.J.H., M.S.S., A.L.J.), Department of Biostatistics (D.L.), and Radiology & Radiological Sciences (L.T.D.), Vanderbilt University Medical Center; and Vanderbilt University School of Medicine (B.S.P.), Nashville, TN. angela.jefferson@vumc.org.
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MVanderbilt Memory & Aging ProjectR01AG034962 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2011 to 2025
$24.1MVanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4MTraining in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6MResearch Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1MGenetic Drivers of Resilience to Alzheimer's DiseaseR01AG059716 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2018 to 2022
$4.4MWhite matter and small vessel disease in older adultsR01AG056534 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2017 to 2021
$3.2MCardiovascular predictors of cerebrovascular health in older adultsR01NS100980 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2017 to 2021
$3.0MReplacement and Upgrade of a 3T MR Scanner for ResearchS10OD021771 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2016 to 2016
$2.0MVascular Factors Underlying Abnormal Cognitive AgingR01HL111516 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2012 to 2017
$1.9MRisk factors and prevention targets for abnormal cognitive agingK24AG046373 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2014 to 2023
$1.7MNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NHLBI NIH HHS R01 HL111516NIA NIH HHS F32 AG058395NIA NIH HHS K01 AG049164NIA NIH HHS K23 AG030962NIA NIH HHS K23 AG045966NIA NIH HHS K24 AG046373NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG056534NIA NIH HHS R01 AG059716NICHD NIH HHS U54 HD083211NIGMS NIH HHS R25 GM062459NIH HHS S10 OD021771NIH HHS S10 OD023680NIMH NIH HHS T32 MH064913NINDS NIH HHS R01 NS100980
Abstract
objectiveTo cross-sectionally relate multiple small vessel disease (SVD) neuroimaging markers to cognition among older adults.
methodsVanderbilt Memory & Aging Project participants free of clinical dementia and stroke (n = 327, age 73 ± 7 years, 59% male, 40% with mild cognitive impairment) completed neuropsychological assessment and 3T MRI to measure white matter hyperintensities (WMH), perivascular spaces (PVS), cerebral microbleeds (CMBs), and lacunes. Linear regressions related each SVD marker to neuropsychological performances and adjusted for age, sex, race/ethnicity, education, cognitive diagnosis,
resultsWMH related to the most neuropsychological measures, including the Boston Naming Test, Animal Naming, Coding, Number Sequencing, Executive Function Composite, and Hooper Visual Organization Test performances (
conclusionsAs expected, increased WMH corresponded to poorer performances across multiple cognitive domains. PVS, previously considered a benign neuroimaging feature in older adults, may have important clinical implications because PVS was related to information processing and executive function performances even in combined models. On the basis of models with multiple SVD predictors, WMH, PVS, and CMBs may each reflect a separate pathway of small vessel injury.
Indexed as
CognitionAgedAged, 80 and overBrainCerebrovascular DisordersCross-Sectional StudiesFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Tests
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