Evidence map›Paper›PMID 30814124›Full record

ArticleThe EMBO journal2019

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates

Julio Sainz de Aja, Sergio Menchero, Isabel Rollan, Antonio Barral, Maria Tiana, Wajid Jawaid, Itziar Cossio, Alba Alvarez, Gonzalo Carreño-Tarragona, Claudio Badia-Careaga and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Biology open · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Julio Sainz de AjaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Sergio MencheroCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Isabel RollanCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Antonio BarralCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Maria TianaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Wajid JawaidWellcome-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.
Itziar CossioCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Alba AlvarezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Gonzalo Carreño-TarragonaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Claudio Badia-CareagaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Jennifer NicholsWellcome-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.
Berthold GöttgensWellcome-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.ORCID 0000-0001-6302-5705
Joan IsernCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.ORCID 0000-0002-1401-9779
Miguel ManzanaresCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain mmanzanares@cnic.es.ORCID 0000-0003-4849-2836
Spanish National Centre for Cardiovascular Research · ESWellcome/MRC Cambridge Stem Cell Institute · GBUniversitat Pompeu Fabra · ES

Funding

Medical Research Council MC_PC_12009Wellcome Trust 206328/Z/17/Z
6 · The paper itself

Abstract

Progenitors of the first hematopoietic cells in the mouse arise in the early embryo from

Indexed as

Cell LineageHematopoiesisAnimalsCell DifferentiationEmbryo, MammalianEmbryonic DevelopmentEmbryonic Stem CellsFemaleGene Expression Regulation, DevelopmentalMaleMiceMice, TransgenicNanog Homeobox ProteinPluripotent Stem CellsT-Cell Acute Lymphocytic Leukemia Protein 1Nanog Homeobox ProteinNanog protein, mouseTal1 protein, mouseT-Cell Acute Lymphocytic Leukemia Protein 1erythropoiesisgastrulationNanogprimitive hematopoiesisTal1

Identifiers

PMID30814124
PMCPMC6443201
OpenAlexW2915475047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.