Evidence map›Paper›PMID 30813938›Full record

ArticleBMC public health2019

Area-level deprivation and preterm birth: results from a national, commercially-insured population.

Renee Mehra, Fatma M Shebl, Shayna D Cunningham, Urania Magriples, Eric Barrette, Carolina Herrera, Katy B Kozhimannil, Jeannette R Ickovics

Registry-linked trialAbstract read
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07115823 (A Longitudinal, Cohort Study Investigating the Impact of General Anaesthetic Caesarean Birth, With or Without ICU Admission, on Maternal Mental Health and Mother/Infant Bonding), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07115823 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Longitudinal, Cohort Study Investigating the Impact of General Anaesthetic Caesarean Birth, With or Without ICU Admission, on Maternal Mental Health and Mother/Infant Bonding

TypeobservationalSponsorKing's College LondonRan2025 to 2026Enrolled500ConditionsGeneral Anaesthesia During Pregnancy
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Cerebral visual impairment is permanent but not unchanging.Developmental medicine and child neurology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renee MehraYale School of Public Health, PO Box 208034, New Haven, CT, 06520-8034, USA. renee.mehra@yale.edu.ORCID http://orcid.org/0000-0002-9794-2971
Fatma M SheblYale School of Public Health, PO Box 208034, New Haven, CT, 06520-8034, USA.
Shayna D CunninghamYale School of Public Health, PO Box 208034, New Haven, CT, 06520-8034, USA.
Urania MagriplesDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, PO Box 208063, New Haven, CT, 06520, USA.
Eric BarretteHealth Care Cost Institute, 1100 G Street NW, Suite 600, Washington, DC, 20005, USA.
Carolina HerreraBoston University School of Public Health, 715 Albany Street, Boston, MA, 02118, USA.
Katy B KozhimannilDivision of Health Policy and Management, University of Minnesota School of Public Health, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
Jeannette R IckovicsYale School of Public Health, PO Box 208034, New Haven, CT, 06520-8034, USA.

Funding

Yale Training Program in Health Services ResearchT32HS017589 · AHRQ · YALE UNIVERSITY · PI SCHLESINGER, MARK J · 2008 to 2024
$5.6M
AHRQ HHS T32 HS017589AHRQ HHS T32 HS022242HRSA HHS R40MC28308NIH HHS 5T32HS017589-10
6 · The paper itself

Abstract

backgroundArea-level deprivation is associated with multiple adverse birth outcomes. Few studies have examined the mediating pathways through which area-level deprivation affects these outcomes. The objective of this study was to investigate the association between area-level deprivation and preterm birth, and examine the mediating effects of maternal medical, behavioural, and psychosocial factors.

methodsWe conducted a retrospective cohort study using national, commercial health insurance claims data from 2011, obtained from the Health Care Cost Institute. Area-level deprivation was derived from principal components methods using ZIP code-level data. Multilevel structural equation modeling was used to examine mediating effects.

resultsIn total, 138,487 women with a live singleton birth residing in 14,577 ZIP codes throughout the United States were included. Overall, 5.7% of women had a preterm birth. In fully adjusted generalized estimation equation models, compared to women in the lowest quartile of area-level deprivation, odds of preterm birth increased by 9.6% among women in the second highest quartile (odds ratio (OR) 1.096; 95% confidence interval (CI) 1.021, 1.176), by 11.3% in the third highest quartile (OR 1.113; 95% CI 1.035, 1.195), and by 24.9% in the highest quartile (OR 1.249; 95% CI 1.165, 1.339). Hypertension and infection moderately mediated this association.

conclusionsEven among commercially-insured women, area-level deprivation was associated with increased risk of preterm birth. Similar to individual socioeconomic status, area-level deprivation does not have a threshold effect. Implementation of policies to reduce area-level deprivation, and the screening and treatment of maternal mediators may be associated with a lower risk of preterm birth.

Indexed as

AdultFemaleHumansInfant, NewbornInsurance, HealthLive BirthOdds RatioPovertyPregnancyPremature BirthRetrospective StudiesSocioeconomic FactorsUnited StatesYoung AdultArea-level deprivationCommercially-insuredMediating pathwaysPreterm birth

Identifiers

PMID30813938
PMCPMC6391769

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.