ArticleBMC gastroenterology2019
Case report of patient with a Cronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies.World journal of gastrointestinal pathophysiology · 2026Review
- Cronkhite-Canada Syndrome: A Diagnostic Challenge and Management With Vedolizumab.The American journal of case reports · 2026Article
- Cronkhite-Canada syndrome, hypothyroidism and positive autoantibodies: a case report.Journal of medical case reports · 2026Article
- Cronkhite-Canada syndrome after corticosteroid and mesalazine treatment: A case report and 3-year follow-up.Medicine · 2026Article
- Arrhythmias in Cronkhite-Canada Syndrome.Internal medicine (Tokyo, Japan) · 2025Article
- A Case of Asymptomatic Cronkhite-Canada Syndrome Diagnosed by Endoscopic and Pathological Findings.Cureus · 2025Article
- Spontaneous remission of Cronkhite-Canada syndrome without immunosuppressive medication in the context of decompensated cirrhosis: A case report.Clinical case reports · 2024Article
- Sustained remission of Cronkhite-Canada syndrome after corticosteroid and mesalazine treatment: A case report.World journal of clinical cases · 2024Article
- Comprehensive treatment and a rare presentation of Cronkhite-Canada syndrome: Two case reports and review of literature.World journal of gastrointestinal surgery · 2023Article
- Cronkhite-Canada syndrome: First case report from Egypt and North Africa.World journal of gastrointestinal endoscopy · 2022Article
- Cronkhite-Canada syndrome: A case report and review of the literature.Annals of medicine and surgery (2012) · 2022Article
- Cronkhite-Canada Syndrome Associated With Superficial Esophageal Carcinoma: A Case Report and Literature Review.Frontiers in medicine · 2022Article
- Cronkhite-Canada syndrome with steroid dependency: A case report.World journal of clinical cases · 2021Article
- Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome.Internal medicine (Tokyo, Japan) · 2021Article
- Cronkhite-Canada Syndrome Associated with Gastric Outlet Obstruction and Membranous Nephropathy: A Case Report and Review of the Literature.Internal medicine (Tokyo, Japan) · 2020Review
- Cronkhite-Canada syndrome: from clinical features to treatment.Gastroenterology report · 2020Review
- Successful surgical treatment of Cronkhite-Canada Syndrome with bilateral flail chest: a case report.BMC surgery · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCronkhite-Canada syndrome is a rare disease of unknown etiology and the optimal treatment for this syndrome is unknown. CASE PRESENTATION: We present the case of a man who at the age of 66.0 years was diagnosed with Cronkhite-Canada syndrome (CCS). In addition to watery diarrhea, alopecia, and a complete loss of toenails and fingernails, the patient had been suffering from dysgeusia and rapid weight loss of more than 10.0 kg within a few months. The patient had recently incurred a distal radius fracture. During the initial endoscopy an extensive polyposis of the stomach and jejunum was found. The diagnosis of CCS was made and after initiation of a steroid therapy his diarrhea improved immediately. A discontinuation of the steroid therapy was not possible and mesalazine (1000 mg t.i.d.) was added to prednisolone (10.0 mg/d). This therapy led to a remission within 6.0 months with weight gain and normalization of serum albumin levels. The prednisolone dose was reduced to 7.5 mg/d. During the following year, the steroids could be further reduced and nails had regrown again. Within three years, all polyps had disappeared and the steroid therapy was finished while the dosage of mesalazine was reduced in a stepwise fashion. Four years later, the mesalazine was stopped and more than 14.0 years after the initial diagnosis the patient is still in complete remission without any treatment.
conclusionThe optimal treatment for CCS is unknown. In our case, the initial combination therapy of corticosteroids plus mesalazine followed by a mesalazine monotherapy has led to a remarkable long-lasting remission with complete resolution of all intestinal polyps.
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