Evidence map›Paper›PMID 30813880›Full record

ReviewCurrent cardiology reviews2019

Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart.

Leonid N Maslov, Sergey Y Tsibulnikov, Ekaterina S Prokudina, Sergey V Popov, Alla A Boshchenko, Nirmal Singh, Yi Zhang, Peter R Oeltgen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current cardiology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Do We Really Need Aspirin Loading for STEMI?Cardiovascular drugs and therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leonid N MaslovLaboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation.
Sergey Y TsibulnikovLaboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation.
Ekaterina S ProkudinaLaboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation.
Sergey V PopovLaboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation.
Alla A BoshchenkoLaboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation.
Nirmal SinghDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
Yi ZhangDepartment of Physiology, Hebei Medical University, Shijiazhuang, China.
Peter R OeltgenDepartment of Pathology, University of Kentucky College of Medicine, Lexington, KY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.

Indexed as

FemaleHeartHumansIschemiaIschemic PostconditioningMaleMyocardial Reperfusion InjuryMyocardiumSignal Transductionautonomic nervous systemend effectorHearthumoral factorischemiaremote postconditioningreperfusionsignaling.

Identifiers

PMID30813880
PMCPMC6719390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.