Evidence map›Paper›PMID 30813600›Full record

ArticleInternational journal of molecular sciences2019

Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in

Masato Kinboshi, Saki Shimizu, Tomoji Mashimo, Tadao Serikawa, Hidefumi Ito, Akio Ikeda, Ryosuke Takahashi, Yukihiro Ohno

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. CRISPR-edited iPSCs reveal BSN gene mutations induce neuronal hyperexcitability via astrocyte lipid accumulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Investigating Developmental and Epileptic Encephalopathy UsingInternational journal of molecular sciences · 2020
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Masato KinboshiDepartment of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. kinboshi@kuhp.kyoto-u.ac.jp.ORCID 0000-0002-5556-8336
Saki ShimizuDepartment of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. s.shimizu@gly.oups.ac.jp.
Tomoji MashimoInstitute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. mashimo@iexas.med.osaka-u.ac.jp.
Tadao SerikawaDepartment of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. serikawa@anim.med.kyoto-u.ac.jp.
Hidefumi ItoDepartment of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan. itohid@kuhp.kyoto-u.ac.jp.
Akio IkedaDepartment of Epilepsy, Movement Disorders and Physiology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. akio@kuhp.kyoto-u.ac.jp.
Ryosuke TakahashiDepartment of Neurology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. ryosuket@kuhp.kyoto-u.ac.jp.
Yukihiro OhnoDepartment of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. yohno@gly.oups.ac.jp.
Osaka University of Pharmaceutical Sciences · JPKyoto University · JPWakayama Medical University · JPThe University of Osaka · JP

Funding

Japan Agency for Medical Research and Development 17ek0109120h0003Ministry of Education, Culture, Sports, Science and Technology 15H04270Ministry of Education, Culture, Sports, Science and Technology 15H04892Ministry of Education, Culture, Sports, Science and Technology 15H05874Ministry of Education, Culture, Sports, Science and Technology 16K21501Ministry of Education, Culture, Sports, Science and Technology 17K08324
6 · The paper itself

Abstract

The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Here, we analyzed the Kir4.1 expressional changes in

Indexed as

Down-RegulationAcousticsAnimalsAstrocytesDisease SusceptibilityEpilepsy, ReflexGlial Fibrillary Acidic ProteinIntercellular Signaling Peptides and ProteinsKcnj10 ChannelMaleMutationPotassium Channels, Inwardly RectifyingProteinsRats, Inbred F344Valproic AcidGlial Fibrillary Acidic ProteinIntercellular Signaling Peptides and ProteinsKcnj10 ChannelLgi1 protein, ratPotassium Channels, Inwardly RectifyingProteinsValproic AcidADLTEantiepilepticsastrocytesepilepsyKir4.1 channelsLgi1valproic acid

Identifiers

PMID30813600
PMCPMC6429235
OpenAlexW2915549063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.