ArticleDiagnostics (Basel, Switzerland)2019
Understanding Real-Time Fluorescence Signals from Bacteria and Wound Tissues Observed with the MolecuLight i:X
Article in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review.International wound journal · 2025Pooled it
- Systematic review and meta-analysis of diagnostic test accuracy in chronic wound's microbiology.International wound journal · 2024Pooled it
- Guidelines for Point-of-Care Fluorescence Imaging for Detection of Wound Bacterial Burden Based on Delphi Consensus.Diagnostics (Basel, Switzerland) · 2021Guideline
- Article
- Photoinduced Fluorescence Changes in Selected Bacterial Strains Under 405 nm Laser Excitation: An In Vitro Hue-Based Monitoring Approach.Micromachines · 2026Article
- Absence of Bacterial Fluorescence Is Associated With Early Response to Skin Substitutes in Diabetic and Venous Ulcers: A Single-Blinded Prospective Study.International wound journal · 2026Observational
- Silk Fibroin for Biomedical Applications with Emphasis on Bioimaging, Biosensing and Regenerative Systems: A Review.Molecules (Basel, Switzerland) · 2026Review
- Smartphone-based multispectral autofluorescence analysis of bacteria mixtures of staphylococci using convolutional neural network.Journal of biological engineering · 2026Article
- A Scoping Review of Fluorescence Imaging: A Promising New Technology for Bacterial Detection in Burn Wounds.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Real-time detection and monitoring of bacteria in diabetic wounds using bacterial fluorescence.Frontiers in microbiology · 2026Article
- How Can Technology Improve Burn Wound Care: A Review of Wound Imaging Technologies and Their Application in Burns-UK Experience.Diagnostics (Basel, Switzerland) · 2025Review
- New Application for the Early Detection of Wound Infections Using a Near-Infrared Fluorescence Device and Forward-Looking Thermal Camera.Diagnostics (Basel, Switzerland) · 2025Article
- Trypan Blue Image-Guided Removal of Surface-Based Bacterial Biofilms from Chicken Tissue Using Cold Atmospheric Pressure Plasma.Plasma (Basel, Switzerland) · 2025Article
- Autofluorescence properties of wound-associated bacteria cultured under various temperature, salinity, and pH conditions.BMC microbiology · 2025Article
- Current and Future Directions in Fluorescence Imaging-Guided Debridement.Advances in wound care · 2025Review
- Prospective evaluation of the Moleculight i:X™ in the early detection of driveline infections.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Audit of Antimicrobial Prescribing Trends in 1447 Outpatient Wound Assessments: Baseline Rates and Impact of Bacterial Fluorescence Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- Wound management materials and technologies from bench to bedside and beyond.Nature reviews. Materials · 2024Article
- Determination of the Course of Cyan Fluorescence ofDiagnostics (Basel, Switzerland) · 2024Article
- How effective is simple mechanical wound debridement in reducing bacterial colonisation? Results of a prospective clinical study.International wound journal · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistent presence of pathogenic bacteria is one of the main obstacles to wound healing. Detection of wound bacteria relies on sampling methods, which delay confirmation by several days. However, a novel handheld fluorescence imaging device has recently enabled real-time detection of bacteria in wounds based on their intrinsic fluorescence characteristics, which differ from those of background tissues. This device illuminates the wound with violet (405 nm) light, causing tissues and bacteria to produce endogenous, characteristic fluorescence signals that are filtered and displayed on the device screen in real-time. The resulting images allow for rapid assessment and documentation of the presence, location, and extent of fluorescent bacteria at moderate-to-heavy loads. This information has been shown to assist in wound assessment and guide patient-specific treatment plans. However, proper image interpretation is essential to assessing this information. To properly identify regions of bacterial fluorescence, users must understand: (1) Fluorescence signals from tissues (e.g., wound tissues, tendon, bone) and fluids (e.g., blood, pus); (2) fluorescence signals from bacteria (red or cyan); (3) the rationale for varying hues of both tissue and bacterial fluorescence; (4) image artifacts that can occur; and (5) some potentially confounding signals from non-biological materials (e.g., fluorescent cleansing solutions). Therefore, this tutorial provides clinicians with a rationale for identifying common wound fluorescence characteristics. Clinical examples are intended to help clinicians with image interpretation-with a focus on image artifacts and potential confounders of image interpretation-and suggestions of how to overcome such challenges when imaging wounds in clinical practice.
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