Evidence map›Paper›PMID 30813513›Full record

ReviewCancers2019

Brain Metastases from Lung Cancer: Is MET an Actionable Target?

Giulia M Stella, Alessandra Corino, Giulia Berzero, Stefan Kolling, Andrea R Filippi, Silvia Benvenuti

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Assessment of Effective Dose Received in Various Computed Tomography Protocols and Factors Affecting It.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Giulia M StellaDepartment of Medical Sciences and Infectious Diseases, Unit of Respiratory System Diseases, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy. G.Stella@smatteo.pv.it.ORCID 0000-0003-0929-4394
Alessandra CorinoDepartment of Medical Sciences and Infectious Diseases, Unit of Respiratory System Diseases, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy. corinoalessandra@gmail.com.
Giulia BerzeroIRCCS Istituto Casimiro Mondino, 27100 Pavia, Italy. giulia.berzero@mondino.it.
Stefan KollingDepartment of Medical Sciences and Infectious Diseases, Unit of Respiratory System Diseases, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy. stefan.kolling01@universitadipavia.it.
Andrea R FilippiDepartment of Medical Sciences and Infectious Diseases, Unit of Radiation Therapy, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy. a.filippi@smatteo.pv.it.ORCID 0000-0001-7159-7869
Silvia BenvenutiDepartment of Molecular Therapeutics and Exploratory Research, IRCCS Candiolo Cancer Institute, 10060 Candiolo, Italy. silvia.benvenuti@ircc.it.
Policlinico San Matteo Fondazione · ITCandiolo Cancer Institute · ITFondazione Istituto Neurologico Nazionale Casimiro Mondino · IT

Funding

Fondazione IRCCS Policlinico San Matteo 20180104754
6 · The paper itself

Abstract

The process of metastatic dissemination begins when malignant cells start to migrate and leave the primary mass. It is now known that neoplastic progression is associated with a combination of genetic and epigenetic events. Cancer is a genetic disease and this pathogenic concept is the basis for a new classification of tumours, based precisely on the presence of definite genetic lesions to which the clones are addicted. Regarding the scatter factor receptors MET and Recepteur d'Origin Nantais (RON), it is recognised that MET is an oncogene necessary for a narrow subset of tumours (MET-addicted) while it works as an adjuvant

Indexed as

actionable targetBrain metastasesInvasive GrowthLung Cancer

Identifiers

PMID30813513
PMCPMC6468667
OpenAlexW2917258933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.