ReviewJournal of cardiovascular development and disease2019
Hypoplastic Left Heart Syndrome: A New Paradigm for an Old Disease?
Review in Journal of cardiovascular development and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- Improved outcomes after modified Stage I palliation for hypoplastic left heart syndrome.JTCVS open · 2026Article
- Hypoplastic Left Heart Syndrome in U.S. Children: A 20-Year Look at Lives Lost and Gaps That Remain.Pediatric cardiology · 2026Article
- Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Current practice and challenges in fetal cardiac intervention.Frontiers in cardiovascular medicine · 2026Review
- Short and Mid-term Outcomes of Ductal Graft with Bilateral Pulmonary Banding in Hypoplastic Left Heart Syndrome and Variants.Pediatric cardiology · 2025Article
- Hypoplastic left heart syndrome-a scoping review.Translational pediatrics · 2025Review
- Maternal Diabetes and Overweight and Congenital Heart Defects in Offspring.JAMA network open · 2024Article
- Navigating family life with Hypoplastic Left Heart Syndrome: A qualitative study.PLOS mental health · 2024Article
- Patterns of Aortic Dilation in Tetralogy of Fallot: An Analysis of 100 Fetal Echocardiograms Compared With Matched Controls.Journal of the American Heart Association · 2023Article
- Cardiac magnetic resonance imaging findings of isolated left ventricular apical hypoplasia.Journal of cardiology cases · 2023Article
- Case Report: 5 Cases of Variant Hypoplastic Left Heart Syndrome Diagnosed on Prenatal Fetal Ultrasound.The American journal of case reports · 2023Article
- Rare variants inHGG advances · 2023Article
- Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling.Communications biology · 2023Article
- Article
- Converting an infant with borderline left heart structures to biventricular circulation after an initial hybrid Norwood approach: a case report.European heart journal. Case reports · 2023Article
- Hypoplastic Left Heart Syndrome: About a Postnatal Death.Diagnostics (Basel, Switzerland) · 2023Article
- Use of Frogs as a Model to Study the Etiology of HLHS.Journal of cardiovascular development and disease · 2023Article
- Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency.Circulation research · 2023Article
- ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.Human molecular genetics · 2022Article
- Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome.Nature communications · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoplastic left heart syndrome occurs in up to 3% of all infants born with congenital heart disease and is a leading cause of death in this population. Although there is strong evidence for a genetic component, a specific genetic cause is only known in a small subset of patients, consistent with a multifactorial etiology for the syndrome. There is controversy surrounding the mechanisms underlying the syndrome, which is likely due, in part, to the phenotypic variability of the disease. The most commonly held view is that the "decreased" growth of the left ventricle is due to a decreased flow during a critical period of ventricular development. Research has also been hindered by what has been, up until now, a lack of genetically engineered animal models that faithfully reproduce the human disease. There is a growing body of evidence, nonetheless, indicating that the hypoplasia of the left ventricle is due to a primary defect in ventricular development. In this review, we discuss the evidence demonstrating that, at least for a subset of cases, the chamber hypoplasia is the consequence of hyperplasia of the contained cardiomyocytes. In this regard, hypoplastic left heart syndrome could be viewed as a neonatal form of cardiomyopathy. We also discuss the role of the endocardium in the development of the ventricular hypoplasia, which may provide a mechanistic basis for how impaired flow to the developing ventricle leads to the anatomical changes seen in the syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.