Evidence map›Paper›PMID 30813346›Full record

ArticleCancers2019

A Retrospective Dosimetric Study of Radiotherapy Patients with Left-Sided Breast Cancer; Patient Selection Criteria for Deep Inspiration Breath Hold Technique.

Mikaela Dell'Oro, Eileen Giles, Amy Sharkey, Martin Borg, Caroline Connell, Eva Bezak

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mikaela Dell'OroCancer Research Institute and School of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia. mikaela.delloro@mymail.unisa.edu.au.ORCID 0000-0002-1459-1820
Eileen GilesCancer Research Institute and School of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia. eileen.giles@unisa.edu.au.
Amy SharkeyGenesisCare, Adelaide, SA 5000, Australia. Amy.Sharkey@genesiscare.com.
Martin BorgGenesisCare, Adelaide, SA 5000, Australia. hughes46@tpg.com.au.ORCID 0000-0003-0902-1548
Caroline ConnellGenesisCare, Adelaide, SA 5000, Australia. Caroline.Connell@genesiscare.com.
Eva BezakCancer Research Institute and School of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia. Eva.Bezak@unisa.edu.au.ORCID 0000-0002-1315-1735
Genesis HealthCare · USUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have investigated cardiac dose reduction when utilizing the deep inspiration breath hold (DIBH) technique in patients undergoing radiotherapy for left-sided breast cancer. This paper aims to recommend potential selection criteria based on a retrospective single institute study of free breathing (FB) and DIBH computed tomography (CT) simulation planning scans.

methodsDosimetric comparisons were performed retrospectively for 20 patients correlating the dose reduction and patient anatomical factors (anatomical variation of chest shape, chest wall separation, total lung volume (TLV) and others).

resultsPaired t-tests demonstrated significant cardiac dose reduction for most patients but not all. Minimal cardiac dose reduction was observed for three patients using their DIBH plan, with one patient receiving a higher dose. Linear regression analysis identified a positive correlation between the patient's TLV (on the FB CT simulation scan) and the magnitude of dosimetric benefit received (0.4045 R²).

conclusionThe TLV measured on a FB plan could potentially be utilised to predict cardiac exposure and assist with patient selection for DIBH. This is important in resource allocation, as DIBH may be unnecessarily recommended for some patients with little dosimetric benefit.

Indexed as

chest wall separationCWSDeep inspiration breath holdDIBHleft-sided breast cancerselection criteriaTLVtotal lung volume

Identifiers

PMID30813346
PMCPMC6406815
OpenAlexW2916771221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.