ArticleInternational journal of molecular sciences2019
Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21.
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Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Perfluorooctane sulfonate (PFOS) interferes with Cyp1a activity and dysregulates the aryl hydrocarbon receptor pathway in larval zebrafish (Danio rerio).Environmental pollution (Barking, Essex : 1987) · 2026Article
- Chronic Exposure to 2,3,7,8-Tetrachlorodibenzofuran Induces Obesogenic Effects on Mice Fed Normal or Western Diets.Environment & health (Washington, D.C.) · 2026Article
- Mature adipocytes lack functional Aryl Hydrocarbon Receptor - a study investigating its role in diet-induced obesity in mice.Wellcome open research · 2026Article
- Drug-Induced Glucose Metabolism Disorders: Role of Aryl Hydrocarbon Receptor.Journal of xenobiotics · 2025Review
- Orchestration of Gut-Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic Innovation.Biomedicines · 2025Review
- Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating aryl hydrocarbon receptor-dependent AMPK signaling.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3.Frontiers in pharmacology · 2025Article
- AhR governs lipid metabolism: the role of gut microbiota.Frontiers in microbiology · 2025Review
- Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity.Redox biology · 2024Article
- Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis.Molecular metabolism · 2024Article
- Article
- The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022.International journal of molecular sciences · 2023Article
- Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease.Receptors (Basel, Switzerland) · 2023Article
- Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis.International journal of molecular sciences · 2022Review
- Obesity I: Overview and molecular and biochemical mechanisms.Biochemical pharmacology · 2022Review
- Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver.Acta pharmaceutica Sinica. B · 2021Article
- Liver-Specific Nonviral Gene Delivery of Fibroblast Growth Factor 21 Protein Expression in Mice Regulates Body Mass and White/Brown Fat Respiration.The Journal of pharmacology and experimental therapeutics · 2021Article
- The Aryl Hydrocarbon Receptor in Energy Balance: The Road from Dioxin-Induced Wasting Syndrome to Combating Obesity with Ahr Ligands.International journal of molecular sciences · 2020Review
- The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepatic neutral lipids in zebrafish larvae (Danio rerio).Chemosphere · 2020Article
- Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Nathaniel G GirerDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. ngirer89@gmail.com.
Dwayne CarterDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. dwaynecarter1981@gmail.com.
Nisha BhattaraiDivision of Surgical Sciences, Department of Surgery, UTMB & Metabolism Unit, Shriners Hospitals for Children, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. nibhatta@utmb.edu.
Mehnaz MustafaDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. mehnazmustafa.mehnaz3@gmail.com.
Larry DennerDepartment of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. ladenner@utmb.edu.
Craig PorterDivision of Surgical Sciences, Department of Surgery, UTMB & Metabolism Unit, Shriners Hospitals for Children, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. cr2porte@utmb.edu.
Cornelis J ElferinkDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. coelferi@utmb.edu.
The University of Texas Medical Branch at Galveston · USShriners Hospitals for Children - Galveston · US
Funding
Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MMolecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6MUTMB Clinical and Translational Science AwardKL2TR001441 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AMEREDES, BILL T · 2015 to 2024
$4.0MAryl Hydrocarbon Receptor-Mediated Epigenetic ProcessesR01ES026874 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 2016 to 2020
$2.2MHepatic Aryl Hydrocarbon Receptor Regulation of Obesity: Mechanisms of ActionR01ES033682 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Casey W Wright · 2022 to 2026
$1.8MMechanistic Insights into Aryl Hydrocarbon Receptor Regulation of Fibroblast Growth Factor 21 and its Influence on Systemic Energy MetabolismF32DK116489 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GIRER, NATHANIEL · 2019 to 2019
$61kRADIATION-INDUCED DNA DAMAGE AND REPAIR IN EUKARYOTESK04CA001441 · NCI · EMORY UNIVERSITY · PI DOETSCH, PAUL W. · 1989 to 1993
–NCATS NIH HHS KL2TR001441NIDDK NIH HHS F32 DK116489NIEHS NIH HHS P30 ES030285NIEHS NIH HHS R01 ES026874NIEHS NIH HHS R01 ES033682NIEHS NIH HHS T32ES007254NIH HHS P30ES006676NIH HHS R01ES026874
Abstract
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor highly expressed in hepatocytes. Researchers have employed global and liver-specific conditional
Indexed as
Cell RespirationThermogenesisAdipose Tissue, BrownAdipose Tissue, WhiteAdiposityAnimalsBody WeightDiet, High-FatDrinkingEnergy MetabolismFeeding BehaviorFemaleFibroblast Growth FactorsGonadsHepatocytesLipid Dropletsfibroblast growth factor 21Fibroblast Growth FactorsReceptors, Aryl HydrocarbonTamoxifenaryl hydrocarbon receptorfibroblast growth factor 21uncoupling protein 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.