ReviewInternational journal of molecular sciences2019
Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter?
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.Annals of general psychiatry · 2026Article
- Serotonin syndrome risk with concomitant opioid and serotonergic antidepressant use: a multinational pharmacovigilance study.Frontiers in pharmacology · 2026Article
- Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder.BMC psychiatry · 2025Article
- Treatment-resistant depression: molecular mechanisms and management.Molecular biomedicine · 2024Review
- Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose-response study.Biology of sex differences · 2023Article
- Revisiting the antidepressant-like effects of desipramine in male and female adult rats: sex disparities in neurochemical correlates.Pharmacological reports : PR · 2022Article
- Exploring pharmacological options for adolescent depression: a preclinical evaluation with a sex perspective.Translational psychiatry · 2022Article
- Developing symptom clusters: linking inflammatory biomarkers to depressive symptom profiles.Translational psychiatry · 2022Article
- Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK).Neurobiology of stress · 2021Article
- Hypothalamic-Pituitary-End-Organ Axes: Hormone Function in Female Patients with Major Depressive Disorder.Neuroscience bulletin · 2021Review
- Sex differences in pharmacological treatment of major depressive disorder: results from the AMSP pharmacovigilance program from 2001 to 2017.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress.Biological trace element research · 2021Article
- Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration.International journal of molecular sciences · 2020Article
- Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020Article
- Molecular Psychiatry: Trends and Study Examples.International journal of molecular sciences · 2020Article
- Comorbid Premenstrual Dysphoric Disorder in Women with Bipolar Disorder: Management Challenges.Neuropsychiatric disease and treatment · 2020Review
- Antidepressant-like effects of the Guanxin Danshen formula via mediation of the CaMK II-CREB-BDNF signalling pathway in chronic unpredictable mild stress-induced depressive rats.Annals of translational medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Gender differences play a pivotal role in the pathophysiology and treatment of major depressive disorder. This is strongly supported by a mean 2:1 female-male ratio of depression consistently observed throughout studies in developed nations. Considering the urgent need to tailor individualized treatment strategies to fight depression more efficiently, a more precise understanding of gender-specific aspects in the pathophysiology and treatment of depressive disorders is fundamental. However, current treatment guidelines almost entirely neglect gender as a potentially relevant factor. Similarly, the vast majority of animal experiments analysing antidepressant treatment in rodent models exclusively uses male animals and does not consider gender-specific effects. Based on the growing interest in innovative and rapid-acting treatment approaches in depression, such as the administration of ketamine, its metabolites or electroconvulsive therapy, this review article summarizes the evidence supporting the importance of gender in modulating response to rapid acting antidepressant treatment. We provide an overview on the current state of knowledge and propose a framework for rodent experiments to ultimately decode gender-dependent differences in molecular and behavioural mechanisms involved in shaping treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.