ArticleCell reports2019
Signal Integration by Shadow Enhancers and Enhancer Duplications Varies across the Drosophila Embryo.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Enhancer placement impacts transcriptional dynamics in Drosophila embryos.Nature communications · 2026Article
- Enhancer Trajectories in Lineage Commitment: Regulatory Logic of States and Cooperation.Biomolecules · 2026Review
- Deep learning-based high-resolution time inference for deciphering dynamic gene regulation from fixed embryos.Nature communications · 2025Article
- Two coacting shadow enhancers regulate twin of eyeless expression during early Drosophila development.Genetics · 2025Article
- A mathematical model clarifies the ABC Score formula used in enhancer-gene prediction.bioRxiv : the preprint server for biology · 2024Article
- Development and evolution of Drosophila chromatin landscape in a 3D genome context.Nature communications · 2024Article
- Interpreting cis-regulatory interactions from large-scale deep neural networks.Nature genetics · 2024Article
- InterpretingbioRxiv : the preprint server for biology · 2024Article
- Review
- Cis-regulatory Landscape Size, Constraint, and Tissue Specificity Associate with Gene Function and Expression.Genome biology and evolution · 2023Article
- Shadow enhancers mediate trade-offs between transcriptional noise and fidelity.PLoS computational biology · 2023Article
- Transcriptional activators in the early Drosophila embryo perform different kinetic roles.Cell systems · 2023Article
- Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus.Molecular cell · 2023Article
- On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation.Nature communications · 2022Article
- Shadow enhancers modulate distinct transcriptional parameters that differentially effect downstream patterning events.Development (Cambridge, England) · 2022Article
- Differential regulation of alternative promoters emerges from unified kinetics of enhancer-promoter interaction.Nature communications · 2022Article
- Review
- Transcriptional enhancers and their communication with gene promoters.Cellular and molecular life sciences : CMLS · 2021Review
- A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle.PLoS genetics · 2021Article
- Enhancer redundancy in development and disease.Nature reviews. Genetics · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription driven by a pair of shadow enhancers, each enhancer of the pair separately, and each duplicated, using live imaging in Drosophila embryos. This set of constructs allows us to quantify the input-output function describing signal integration by two enhancers. We show that signal integration performed by these shadow enhancers and duplications varies across the expression pattern, implying that how their activities are combined depends on the transcriptional regulators bound to the enhancers in different parts of the embryo. Characterizing signal integration by multiple enhancers is a critical step in developing conceptual and computational models of gene expression at the locus level, where multiple enhancers control transcription together.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.