ArticleCell reports2019
State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Parvalbumin cell state dynamics regulate gamma oscillations and are disrupted in Alzheimer's disease.Neuron · 2026Article
- Spatiotemporally dynamic noradrenergic regulation of cortical networks.bioRxiv : the preprint server for biology · 2026Article
- Selective filtering of relevant sensory signals in parietal cortex.Research square · 2026Article
- Parietal cortex is causally required for state-dependent decisions.Cell reports · 2025Article
- Roles for somatostatin and parvalbumin interneurons in learning and arousal during trace conditioning.iScience · 2025Article
- Parietal cortex is causally required for state-dependent decisions.bioRxiv : the preprint server for biology · 2025Article
- Distinct subpopulations of parvalbumin neurons participating in divergent prefrontal functions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.bioRxiv : the preprint server for biology · 2025Article
- Local Differences in Network Organization in the Auditory and Parietal Cortex, Revealed with Single Neuron Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Thalamocortical architectures for flexible cognition and efficient learning.Trends in cognitive sciences · 2024Review
- Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types.Nature communications · 2024Article
- Article
- Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice.Nature communications · 2024Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Spontaneous variations in arousal modulate subsequent visual processing and local field potential dynamics in the ferret during quiet wakefulness.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Arousal and Locomotion Differently Modulate Activity of Somatostatin Neurons across Cortex.eNeuro · 2023Article
- From pupil to the brain: New insights for studying cortical plasticity through pupillometry.Frontiers in neural circuits · 2023Review
- Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type.NeuroImage · 2022Article
- Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbumin-expressing inhibitory neurons, which exert state-dependent control of network gain and spike patterns, cluster into two stable and functionally distinct subnetworks that are differentially engaged by ascending neuromodulation. One group is excited as a function of increased arousal state; this excitation is driven in part by the increase in cortical norepinephrine that occurs when the locus coeruleus is active. A second group is suppressed during movement when acetylcholine is released into the cortex via projections from the nucleus basalis. These data establish the presence of functionally independent subnetworks of Parvalbumin (PV) cells in the upper layers of the neocortex that are differentially engaged by the ascending reticular activating system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.