ArticleLangmuir : the ACS journal of surfaces and colloids2019
Controlling the Spatial Distribution of Solubilized Compounds within Copolymer Micelles.
Article in Langmuir : the ACS journal of surfaces and colloids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Characterization of dynamics of encapsulated small molecule Nile red in biodegradable polymer using 2D IR methods.The Journal of chemical physics · 2026Article
- Impact of poly(ethylene glycol) functionalized lipids on ordering and fluidity of colloid supported lipid bilayers.Soft matter · 2022Article
- Amphiphilic proteins coassemble into multiphasic condensates and act as biomolecular surfactants.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Co-assembly of precision polyurethane ionomers reveals role of and interplay between individual components.Polymer chemistry · 2021Article
- Dual responsive PMEEECL-PAE block copolymers: a computational self-assembly and doxorubicin uptake study.RSC advances · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
The solubilization of lyophobic compounds in block copolymer micelles has been extensively investigated but remains only partially understood. There is a need to understand the fundamental parameters that determine the spatial distribution of the solubilized compounds within the micelles. Controlling this feature is a key aspect in the design of drug delivery systems with tailored release properties. Using Scheutjens-Fleer self-consistent field (SF-SCF) computations, we found that solubilization is regulated by a complex interplay between enthalpic and entropic contributions and that the spatial distribution can be controlled by the concentration and solubility of the guest compound in the dispersion medium. Upon solubilization, a characteristic change in size and mass of the micelles is predicted. This can be used as a fingerprint to indirectly assess the spatial distribution. Based on these findings, we developed two experimental protocols to control and assess the spatial distribution of lyophobic compounds within block copolymer micelles.
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Registered trials
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