ArticleCancer2019
Analysis of acute myeloid leukemia incidence and geographic distribution in Canada from 1992 to 2010 reveals disease clusters in Sarnia and other industrial US border cities in Ontario.
Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Spatial distribution of acute myeloid leukaemia in Denmark.Environmental health : a global access science source · 2025Article
- From code to care: Clinician and researcher perspectives on an optimal therapeutic web portal for acute myeloid leukemia.PloS one · 2024Article
- Epidemiological characteristics of leukemia in China, 2005-2017: a log-linear regression and age-period-cohort analysis.BMC public health · 2023Article
- Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients.Cell journal · 2023Article
- Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.Frontiers in oncology · 2023Article
- Incidence of myeloid neoplasms in Spain (2002-2013): a population-based study of the Spanish network of cancer registries.Scientific reports · 2022Article
- Population-Based Study Detailing Cutaneous Melanoma Incidence and Mortality Trends in Canada.Frontiers in medicine · 2022Article
- Geographic and Socioeconomic Disparity of Gastric Cancer Patients in Canada.Current oncology (Toronto, Ont.) · 2021Article
- Deconvolution of Bulk Gene Expression Profiles with Single-Cell Transcriptomics to Develop a Cell Type Composition-Based Prognostic Model for Acute Myeloid Leukemia.Frontiers in cell and developmental biology · 2021Article
- Associations Between the Density of Oil and Gas Infrastructure and the Incidence, Stage and Outcomes of Solid Tumours: A Population-Based Geographic Analysis.Frontiers in oncology · 2021Article
- Investigating epidemiologic trends and the geographic distribution of patients with anal squamous cell carcinoma throughout Canada.Current oncology (Toronto, Ont.) · 2020Article
- Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.Current oncology (Toronto, Ont.) · 2020Article
- An emerging trend of rapid increase of leukemia but not all cancers in the aging population in the United States.Scientific reports · 2019Article
- Incidence and mortality trends and geographic patterns of follicular lymphoma in Canada.Current oncology (Toronto, Ont.) · 2019Article
- Environmental and Other Extrinsic Risk Factors Contributing to the Pathogenesis of Cutaneous T Cell Lymphoma (CTCL).Frontiers in oncology · 2019Article
- Article
- Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy.Cancer control : journal of the Moffitt Cancer CenterArticle
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14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral risk factors have been implicated in acute myeloid leukemia (AML) leukemogenesis. However, the epidemiologic distribution and precise triggers for AML in Canada remain poorly understood.
methodsIn this study, demographic data for AML patients in Canada from 1992 to 2010 were analyzed using 3 independent population-based cancer registries. The AML incidence and mortality rates were examined at the levels of province/territory, city, and forward sortation area (FSA) postal code.
resultsIn total, 18,085 patients were identified. AML incidence was documented to be 30.61 cases per million individuals per year (95% confidence interval [CI], 30.17-31.06) from 1992 to 2010. Five industrial cities in Ontario were identified where incidence rates were significantly higher than the national average: Sarnia, Sault Ste. Marie, Thunder Bay, St. Catharines, and Hamilton. Analysis at the FSA postal code level identified significant patient clusters of AML in these cities. Specifically, FSA N7V in Sarnia, Ontario had an incidence of 106.81 (95% CI, 70.96-161.86) cases per million individuals per year, which is >3 times higher than the national average. The pollution from local oil refineries and chemical plants in Sarnia may be implicated as a risk factor for AML in that city. Analysis of mortality rates at the province and city levels corroborated the findings from the incidence data.
conclusionThese results provide a comprehensive analysis of AML burden in Canada and reveal striking geographic case clustering in industrial Ontario cities and potentially implicate exposure to materials/pollution from these plants as an important risk factor for developing AML in Canada.
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