ArticlePloS one2019
Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of Moderate Combined Resistance- and Aerobic-Exercise for 12 Weeks on Body Composition, Cardiometabolic Risk Factors, Blood Pressure, Arterial Stiffness, and Physical Functions, among Obese Older Men: A Pilot Study.International journal of environmental research and public health · 2020Trial
- Review
- Arterial Stiffness and Acute Kidney Injury in the Atherosclerosis Risk in Communities (ARIC) Study.Kidney medicine · 2025Article
- Peripheral vs. Central Arterial Stiffness and Cardiovascular Events in Older Adults: The Atherosclerosis Risk in Communities (ARIC) study.European journal of preventive cardiology · 2025Article
- Accelerated Vascular Aging as a Possible Mechanism of Troponin I Release in the Absence of Clinically Manifested Myocardial Injury.Journal of the American Heart Association · 2025Observational
- Association of central arterial stiffness with atrial myopathy: the Atherosclerosis Risk in Communities (ARIC) study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Acute effects of low-intensity one-legged electrical muscle stimulation on arterial stiffness in experimental and control limbs.Scientific reports · 2024Article
- Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis.Journal of personalized medicine · 2024Article
- Association of Segment-Specific Pulse Wave Velocity With Vascular Calcification: The ARIC (Atherosclerosis Risk in Communities) Study.Journal of the American Heart Association · 2024Article
- Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms.JVS-vascular science · 2024Review
- Associations of blood biomarkers with arterial stiffness in patients with diabetes mellitus: A population-based study.Journal of diabetes · 2023Article
- Prognostic Value of Aortic Stiffness using Cardiovascular Magnetic Resonance in The Elderly with Known or Suspected Coronary Artery Disease.Arquivos brasileiros de cardiologia · 2022Article
- Investigation of the Relationship between Cardiovascular Biomarkers and Brachial-Ankle Pulse Wave Velocity in Hemodialysis Patients.Journal of personalized medicine · 2022Article
- Associations of lower-limb atherosclerosis and arteriosclerosis with cardiovascular risk factors and disease in older adults: The Atherosclerosis Risk in Communities (ARIC) study.Atherosclerosis · 2022Article
- Association of arterial stiffness with incident atrial fibrillation: a cohort study.BMC cardiovascular disorders · 2021Article
- Associations between carotid-femoral and heart-femoral pulse wave velocity in older adults: the Atherosclerosis Risk In Communities study.Journal of hypertension · 2020Article
- Acute Changes in Carotid-Femoral Pulse-Wave Velocity Are Tracked by Heart-Femoral Pulse-Wave Velocity.Frontiers in cardiovascular medicine · 2020Article
- Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study.Frontiers in cardiovascular medicine · 2020Article
- Arterial Stiffness Assessed by Cardio-Ankle Vascular Index.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundArterial stiffness independently predicts cardiovascular disease. However, few studies have evaluated the associations of central and peripheral pulse wave velocity (PWV) with biomarkers of both myocardial stress (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin-T [hs-cTnT]) among persons without cardiac disease.
methodsWe examined 3,348 participants (67-90 years) without prevalent cardiac disease in the Atherosclerosis Risk in Communities (ARIC) Study (2011-13). The cross-sectional associations of PWV quartiles for central arterial segments (carotid-femoral, heart-carotid, heart-femoral) and peripheral artery (femoral-ankle) with NT-proBNP and hs-cTnT were evaluated accounting for potential confounders.
resultsMost PWV measures demonstrated J- or U-shaped associations with the two cardiac biomarkers. The highest (Q4) vs. second lowest (Q2) quartile of central PWV measures (carotid-femoral, heart-carotid, heart-femoral PWV) were associated with higher levels of NT-proBNP independently of demographic characteristics. The associations were less evident for hs-cTnT. These associations were attenuated after adjusting for traditional cardiovascular risk factors, but the heart-carotid PWV-NT-proBNP relationship remained borderline significant (difference in log-NT-proBNP = 0.08 [-0.01, 0.17] in Q4 vs. Q2, p = 0.07). Peripheral PWV demonstrated inverse associations. Higher values of NT-proBNP were seen in the lowest vs. second lowest quartile of all PWV measures.
conclusionsCentral stiffness measures showed stronger associations with cardiac biomarkers (particularly NT-proBNP) than peripheral measures among older adults without cardiac disease. Our findings are consistent with the concept of ventricular-vascular coupling and suggest that central rather than peripheral arterial hemodynamics are more closely related to myocardial stress rather than damage.
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