ArticlePLoS neglected tropical diseases2019
Association of rodent-borne Leptospira spp. with urban environments in Malaysian Borneo.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Leptospirosis in humans and selected animals in Sub-Saharan Africa, 2014-2022: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Zoonotic transmission risk in flood-prone river basins: community knowledge and behavioral determinants of leptospirosis in eastern Ethiopia.BMC public health · 2026Article
- Low detection of Trypanosoma cruzi in invasive Rattus spp. across rural and natural habitats in central Chile.One health outlook · 2026Article
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- Species composition of small mammal communities and prevalence of Schistosoma japonicum in the Poyang Lake region, China.Parasite (Paris, France) · 2026Article
- Epidemiological characteristics of leptospirosis and serological surveillance among reservoir animals and healthy populations in Fujian, China, 2004-2024.Frontiers in public health · 2026Article
- First assessment of plague in terrestrial small mammals and fleas from Makira Natural Park and surroundings, North-eastern Madagascar.PLoS neglected tropical diseases · 2025Article
- Metagenomic insights into host-specific gastroenteritis bacteria in forest rodents of Sarawak, Borneo: implications for one health surveillance of rodent-borne pathogens.BMC microbiology · 2025Article
- Species Composition of a Small Mammal Community and Prevalence ofPathogens (Basel, Switzerland) · 2024Article
- Detection and Identification of PathogenicTransboundary and emerging diseases · 2024Article
- Leptospirosis in Malaysia: current status, insights, and future prospects.Journal of physiological anthropology · 2023Review
- Pathological and molecular study of kidneys in apparently healthy cattle and sheep with special reference toVeterinary world · 2023Article
- Application of Multilocus Sequence Typing for the Characterization ofTropical medicine and infectious disease · 2023Article
- An Overview of Anthropogenic Actions as Drivers for Emerging and Re-Emerging Zoonotic Diseases.Pathogens (Basel, Switzerland) · 2022Review
- Prevalence of PathogenicPathogens (Basel, Switzerland) · 2022Article
- Rats and the city: Implications of urbanization on zoonotic disease risk in Southeast Asia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Internalization of Leptospira interrogans via diverse endocytosis mechanisms in human macrophages and vascular endothelial cells.PLoS neglected tropical diseases · 2022Article
- Leptospirosis in rats and livestock in Bantul and Gunungkidul district, Yogyakarta, Indonesia.Veterinary world · 2022Article
- Presence ofPathogens and global health · 2022Article
- Zoonotic Pathogens in Wildlife Traded in Markets for Human Consumption, Laos.Emerging infectious diseases · 2022Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although leptospirosis is traditionally considered a disease of rural, agricultural and flooded environments, Leptospira spp. are found in a range of habitats and infect numerous host species, with rodents among the most significant reservoirs and vectors. To explore the local ecology of Leptospira spp. in a city experiencing rapid urbanization, we assessed Leptospira prevalence in rodents from three locations in Malaysian Borneo with differing levels of anthropogenic influence: 1) high but stable influence (urban); 2) moderate yet increasing (developing); and 3) low (rural). A total of 116 urban, 122 developing and 78 rural rodents were sampled, with the majority of individuals assigned to either the Rattus rattus lineage R3 (n = 165) or Sundamys muelleri (n = 100). Leptospira spp. DNA was detected in 31.6% of all rodents, with more urban rodents positive (44.8%), than developing (32.0%) or rural rodents (28.1%), and these differences were statistically significant. The majority of positive samples were identified by sequence comparison to belong to known human pathogens L. interrogans (n = 57) and L. borgpetersenii (n = 38). Statistical analyses revealed that both Leptospira species occurred more commonly at sites with higher anthropogenic influence, particularly those with a combination of commercial and residential activity, while L. interrogans infection was also associated with low forest cover, and L. borgpetersenii was more likely to be identified at sites without natural bodies of water. This study suggests that some features associated with urbanization may promote the circulation of Leptospira spp., resulting in a potential public health risk in cities that may be substantially underestimated.
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