ArticleAging2019
Alzheimer's disease as a multistage process: an analysis from a population-based cohort study.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- The multistep pathogenic hypothesis of amyotrophic lateral sclerosis is incompatible with the epidemiological data.European journal of epidemiology · 2026Article
- Multimorbidity as a multistage disease process.PNAS nexus · 2026Article
- Mediation of the Association BetweenNeurology · 2025Article
- Article
- Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases.Translational neurodegeneration · 2023Review
- Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models.Experimental gerontology · 2023Article
- Sporadic, late-onset, and multistage diseases.PNAS nexus · 2022Article
- The common incidence-age multistep model of neurodegenerative diseases revisited: wider general age range of incidence corresponds to fewer disease steps.Cell & bioscience · 2022Article
- Analysis of Time Trends in Alzheimer's Disease and Related Dementias Using Partitioning Approach.Journal of Alzheimer's disease : JAD · 2021Article
- Genealogy of the neurodegenerative diseases based on a meta-analysis of age-stratified incidence data.Scientific reports · 2020Article
- Objectives, design and main findings until 2020 from the Rotterdam Study.European journal of epidemiology · 2020Article
- Predisposition to Alzheimer's and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel.Frontiers in physiology · 2020Article
- Multi-stage models for the failure of complex systems, cascading disasters, and the onset of disease.PloS one · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cancer research, multistage models are used to assess the multistep process that leads to the onset of cancer. In view of biological and clinical similarities between cancer and dementia, we used these models to study Alzheimer's disease (AD). From the population-based Rotterdam Study, we included 9,362 non-demented participants, of whom 1,124 developed AD during up to 26 years of follow-up. Under a multistage model, we regressed the logarithm of AD incidence rate against the logarithm of five-year age categories. The slope in this model reflects the number of steps (n-1) required for disease onset before the final step leading to disease manifestation. A linear relationship between log incidence rate and log age was observed, with a slope of 12.82 (95% confidence interval: 9.01-16.62), equivalent to 14 steps. We observed fewer steps for those at high genetically determined risk: 12 steps for
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