Evidence map›Paper›PMID 30811219›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction.

Hua Lu, Natalia A Cherepanova, Reid Gilmore, Joseph N Contessa, Mark A Lehrman

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Shared host genetic landscape of respiratory viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Preparing for the next viral threat with broad-spectrum antivirals.The Journal of clinical investigation · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hua LuDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Natalia A CherepanovaDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Reid GilmoreDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Joseph N ContessaDepartment of Therapeutic Radiology and Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA.
Mark A LehrmanDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
The University of Texas Southwestern Medical Center · USUniversity of Massachusetts Chan Medical School · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
ASSEMBLY AND TRANSFER OF N-LINKED OLIGOSACCHARIDESR01GM043768 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GILMORE, JAMES REID · 1990 to 2018
$6.9M
The N-Glycosylation Pathway And Signaling By Free Mannose-6-PhosphateR01GM038545 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEHRMAN, MARK · 1987 to 2017
$5.7M
Targeting N-linked Glycosylation to Enhance Radiation TherapyR01CA172391 · NCI · YALE UNIVERSITY · PI CONTESSA, JOSEPH N · 2014 to 2018
$2.0M
Regulation of N-linked glycosylation in Mammalian CellsR01GM127383 · NIGMS · YALE UNIVERSITY · PI CONTESSA, JOSEPH N · 2018 to 2019
$659k
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA172391NIGMS NIH HHS R01 GM038545NIGMS NIH HHS R01 GM043768NIGMS NIH HHS R01 GM127383
6 · The paper itself

Abstract

Herpes simplex virus 1 (HSV-1) is a contagious neurotropic herpesvirus responsible for oral lesions and herpesviral encephalitis. The HSV-1 envelope contains

Indexed as

AnimalsBenzamidesChlorocebus aethiopsEndoplasmic ReticulumGlycosylationHEK293 CellsHerpes SimplexHerpesvirus 1, HumanHexosyltransferasesHumansMembrane ProteinsProtein Processing, Post-TranslationalSulfonamidesVero CellsBenzamidesCID2519269dolichyl-diphosphooligosaccharide - protein glycotransferaseHexosyltransferasesMembrane ProteinsSTT3A protein, humanSulfonamidesglycobiologyglycoproteinglycosylationherpesviruslipid-linked oligosaccharide

Identifiers

PMID30811219
PMCPMC6529348
OpenAlexW2915583832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.