Evidence map›Paper›PMID 30810958›Full record

ArticleNeuroscience bulletin2019

A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance.

Caixia Gong, Zhenhuan Ouyang, Weiqiao Zhao, Jie Wang, Kun Li, Peipei Zhou, Ting Zhao, Nenggan Zheng, Zhefeng Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caixia GongDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Zhenhuan OuyangQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310007, China.
Weiqiao ZhaoDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jie WangDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Kun LiDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Peipei ZhouDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Ting ZhaoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 22011, USA.
Nenggan ZhengQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310007, China. zng@zju.edu.cn.
Zhefeng GongDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China. zfgong@zju.edu.cn.ORCID http://orcid.org/0000-0003-1572-117X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When facing a sudden danger or aversive condition while engaged in on-going forward motion, animals transiently slow down and make a turn to escape. The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown. Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons (the PET pathway). Inhibiting neurons in the PET pathway led to defects in light-avoidance due to insufficient deceleration and head casting. On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses.

Indexed as

LightAnimalsAvoidance LearningBehavior, AnimalDecelerationDrosophilaDrosophila ProteinsInsect HormonesLarvaLocomotionMotor NeuronsNeural PathwaysNeuronsTyrosine DecarboxylaseVisual PathwaysDrosophila Proteinseclosion hormoneInsect Hormonesprothoracicotropic hormoneTyrosine DecarboxylaseDecelerationDrosophilaEH neuronsLarvaLight avoidancePTTH neuronsTdc2 motor neurons

Identifiers

PMID30810958
PMCPMC6864023

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.