ArticleDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2019
[The German keratomycosis registry : Initial results of a multicenter survey].
Article in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis.Translational vision science & technology · 2025Pooled it
- Ophthalmic registries for rare eye diseases.Indian journal of ophthalmology · 2022Pooled it
- Fungal keratitis in Germany : Diagnostics, conservative and microsurgical treatment.Die Ophthalmologie · 2026Review
- Trends in pathogens causing microbial keratitis in studies conducted in Mexico: a 38-year literature review.International ophthalmology · 2026Review
- Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights fromJournal of fungi (Basel, Switzerland) · 2025Article
- Pyrenochaeta unguis-hominis-associated fungal keratitis: A rare case report with in vivo confocal microscopy findings.American journal of ophthalmology case reports · 2025Article
- [Fungal keratitis in Germany : Diagnostics, conservative and microsurgical treatment].Die Ophthalmologie · 2025Review
- [First case description of Eutypella scoparia keratitis].Die Ophthalmologie · 2024Article
- Treatment Strategies for Filamentous Fungi Keratitis.Advances in therapy · 2024Article
- [Bilateral chronic contact lens-associated keratitis].Die Ophthalmologie · 2024Article
- [Surprising histologic findings in a chronic corneal ulcer].Die Ophthalmologie · 2024Article
- Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009-2019.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease.Journal of fungi (Basel, Switzerland) · 2022Review
- [Current and future effects of climate change on ophthalmology].Die Ophthalmologie · 2022Review
- [Purpureocillium lilacinum : Atypical pathogen of mycotic keratitis in an immunocompetent patient].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022Article
- Outcomes of Severe Fungal Keratitis Using in vivo Confocal Microscopy and Early Therapeutic Penetrating Keratoplasty.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from theJournal of fungi (Basel, Switzerland) · 2021Article
- [Coinfections in contact lens-associated mycotic keratitis with Pseudomonas or Acanthamoeba].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Article
- Eye Infections Caused by Filamentous Fungi: Spectrum and Antifungal Susceptibility of the Prevailing Agents in Germany.Journal of fungi (Basel, Switzerland) · 2021Article
- First case ofMedical mycology case reports · 2021Article
Corrections and comments
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Authors and funding
25 authors at 16 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMycotic keratitis is a serious but relatively rare disease. No targeted data collection in Germany existed until the foundation of the German Pilz-Keratitis Register in 2015. PATIENTS AND
methodsThe inclusion of retrospective and prospective patients was carried out. INCLUSION CRITERIA: diagnosis confirmed by the polymerase chain reaction (PCR), culture, histology or confocal microscopy (IVCM). Collected parameters: date of symptom onset, date and method of diagnosis, risk factors, visual acuity and findings at admission and at follow-up, conservative and surgical treatment.
resultsBy January 2018, a total of 102 eyes from the years 2000-2017 were reported from 16 centers (64.3% female, mean age 52 years, range 18-95 years). The initial diagnosis was made correctly in only 20.6% of cases. The mean time to correct diagnosis was 31.7 ± 46.9 (0-296) days. The diagnosis was confirmed in cultures in 74.5%, histologically in 30.4%, by PCR in 38.2% and IVCM in 27.4%. Fungal species identified were: 36.7% Fusarium spp., 35.8% Candida spp., 6.4% Aspergillus spp. and 21.1% other. The most important risk factor was the use of contact lenses. The most commonly used antifungal agent was voriconazole (64.7%) followed by amphotericin B (37.2%). Penetrating keratoplasty was performed in 65.7% of the cases and 8.8% of the affected eyes had to be enucleated. The visual acuity of the entire study population increased from the initial 0.16 ± 0.25 (0.001-1.0) decimal to 0.28 ± 0.34 (0-1.0) decimal.
conclusionThe correct diagnosis of fungal keratitis is often significantly delayed. The treatment can be very difficult and keratoplasty is often necessary. In order to gain a better understanding of this disease, to recognize previously unknown risk factors and, if necessary, a change in the spectrum of pathogens and to identify approaches to treatment optimization, the fungal keratitis registry will be continued.
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