ArticleJournal of gastroenterology2019
Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions.
Article in Journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk assessment of lymph node metastasis and comparison of treatment modalities for low-risk T1b colorectal cancer: a meta-analysis.Surgical endoscopy · 2025Pooled it
- Additional staining for lymphovascular invasion is associated with increased estimation of lymph node metastasis in patients with T1 colorectal cancer: Systematic review and meta-analysis.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2024Pooled it
- Local recurrence after local excision of early rectal cancer: a meta-analysis of completion TME, adjuvant (chemo)radiation, or no additional treatment.The British journal of surgery · 2020Pooled it
- Using contrast-enhancing software to improve sentinel lymph node detection with indocyanine green in colon cancer surgery.Techniques in coloproctology · 2026Article
- Feasibility of a novel slim gastroscope for endoscopic submucosal dissection: A case series (with video).DEN open · 2026Article
- Efficacy of Endoscopic Full Thickness Resection Using the Full-Thickness Resection Device for Submucosal Invasive Colorectal Cancer: The First United States Multicenter Experience.Digestive diseases and sciences · 2026Article
- Predictors of lymph node metastases, recurrence, and survival in patients with pedunculated-type T1 colorectal cancer.Journal of gastroenterology · 2026Article
- Article
- [Technical advances in endoscopic resection : Potential, limits and the necessary interdisciplinary dialogue with surgery].Innere Medizin (Heidelberg, Germany) · 2026Review
- Assessing the accuracy of magnetic resonance imaging in identifying early rectal cancers suitable for endoscopic intermuscular dissection.Endoscopy · 2025Article
- Artificial intelligence-driven prediction of lymph node metastasis in T1 esophageal squamous cell carcinoma using whole slide images.NPJ precision oncology · 2025Article
- Artificial Intelligence Models May Aid in Predicting Lymph Node Metastasis in Patients with T1 Colorectal Cancer.Gut and liver · 2025Article
- Impact of narrow band imaging in prediction of histology of advanced colorectal neoplasia.Scientific reports · 2025Article
- Tumor Budding as a Risk Factor for Lymph Node Metastasis and Local Recurrence in pT1 Colorectal Cancer: A Systematic Review and Meta-Analysis.Gastro hep advances · 2025Review
- Pure Well-differentiated Adenocarcinoma as a Safe Factor for Lymph Node Metastasis and Recurrence of T1 Colorectal Cancer.Journal of the anus, rectum and colon · 2025Article
- Variation in the detection of lymphovascular invasion in T1 colorectal cancer and its impact on treatment: A nationwide Dutch study.United European gastroenterology journal · 2024Article
- The risk factors of lymph node metastasis in early colorectal cancer: a predictive nomogram and risk assessment.International journal of colorectal disease · 2024Article
- Histological Risk Factors for Lymph Node Metastasis in pT1 Colorectal Cancer: Does Submucosal Invasion Depth Really Matter?Current medical science · 2024Article
- Article
- How secure can we expect the surveillance policies to be after the implementation in T1 polyps with carcinoma?World journal of gastrointestinal endoscopy · 2024Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDetermining the depth of invasion of early stage colorectal cancer has been emphasized as a means of improving endoscopic diagnostic accuracy. Recent studies have focused on other pathological risk factors for lymph node metastasis (LNM). We investigated the significance of depth of invasion and predictive properties of other endoscopic findings.
methodsWe retrospectively investigated 846 patients with submucosal invasive (T1) colorectal cancer who received an accurate pathological diagnosis and were treated between January 2005 and December 2016. Pathological risk factors associated with LNM were reviewed. We divided patients into groups: low-risk T1 colorectal cancer (LRC; no risk factors) and high-risk T1 colorectal cancer (HRC; exhibiting lymphovascular invasion, tumor budding grade of 2/3, and/or poor differentiation) and studied predictive endoscopic factors for HRC.
resultsSignificant risk factors for LNM in multivariate analysis were lymphovascular invasion [odds ratio (OR) 8.09; 95% confidence interval (CI) 3.84-17.1], tumor budding (OR 1.89; 95% CI 1.09-3.29), and histological differentiation (OR 2.09; 95% CI 1.12-3.89). The LNM-positive rate with only deep submucosal invasion was 1.6%. Significant predictive factors for HRC in multivariate analysis identified rectal tumor location (OR 1.92; 95% CI 1.35 -2.72, depression (OR 2.73; 95% CI 1.96 -3.80), protuberance within the depression (OR 2.58; 95% CI 1.39- 4.78), expansiveness (OR 2.39; 95% CI 1.27- 4.50), and loss of mucosal patterns (OR 1.90; 95% CI 1.20 -3.01) as significant factors.
conclusionsRectal tumor location, depression, protuberance within the depression, expansiveness, and loss of mucosal patterns could be predictive factors for HRC.
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