ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2019
A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Dietary Fructose and Palmitic Acid Induce Shared and Divergent Transcriptional Responses in the Larval Midgut ofCurrent issues in molecular biology · 2026Article
- Diet Modification Alters Repeated Exposure Ethanol Tolerance Development.microPublication biology · 2026Article
- High-saturated-fat diet drives female-biased neurodegeneration inFrontiers in aging neuroscience · 2026Article
- High-fat diet impairs intermediate-term memory by autophagic-lysosomal dysfunction in Drosophila.PLoS genetics · 2025Article
- Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster.Aging cell · 2024Article
- Screening for Differentially Expressed Memory Genes on a Diabetes Model Induced by High-Sugar Diet in Drosophila melanogaster: Potential Markers for Memory Deficits.Molecular neurobiology · 2024Article
- Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet.Scientific reports · 2023Article
- Effects of Fructose and Palmitic Acid on Gene Expression inInternational journal of molecular sciences · 2023Article
- Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model.Molecules (Basel, Switzerland) · 2023Article
- A protein restricted diet induces a stable increased fat storage phenotype in flies.Toxicology reports · 2023Article
- Article
- Phenotyping ofBiomolecules · 2022Review
- Lipidomic analyses reveal enhanced lipolysis in planthoppers feeding on resistant host plants.Science China. Life sciences · 2021Article
- Article
- Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.FASEB bioAdvances · 2021Article
- Crème de la Créature: Dietary Influences on Behavior in Animal Models.Frontiers in behavioral neuroscience · 2021Article
- What You Eat Matters: Nutrient Inputs Alter the Metabolism and Neuropeptide Expression in Egyptian Cotton Leaf Worm,Frontiers in physiology · 2021Article
- Functional Characterization of Gomisin N in High-Fat-InducedInternational journal of molecular sciences · 2020Article
- Royal Jelly as an Intelligent Anti-Aging Agent-A Focus on Cognitive Aging and Alzheimer's Disease: A Review.Antioxidants (Basel, Switzerland) · 2020Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Obesity predisposes humans to a range of life-threatening comorbidities, including type 2 diabetes and cardiovascular disease. Obesity also aggravates neural pathologies, such as Alzheimer's disease, but this class of comorbidity is less understood. When Drosophila melanogaster (flies) are exposed to high-fat diet (HFD) by supplementing a standard medium with coconut oil, they adopt an obese phenotype of decreased lifespan, increased triglyceride storage, and hindered climbing ability. The latter development has been previously regarded as a potential indicator of neurological decline in fly models of neurodegenerative disease. Our objective was to establish the obesity phenotype in Drosophila and identify a potential correlation, if any, between obesity and neurological decline through behavioral assays and gene expression microarray. We found that mated female w
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