ArticleJMIR research protocols2019
The Stepped Care Intervention to Suppress Viral Load in Youth Living With HIV: Protocol for a Randomized Controlled Trial.
Article in JMIR research protocols, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03109431 (Optimizing the HIV Treatment Continuum With a Stepped Care Model for Youth Living With HIV), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing the HIV Treatment Continuum With a Stepped Care Model for Youth Living With HIV
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Interventions to Improve Treatment Outcomes among Adolescents on Antiretroviral Therapy with Unsuppressed Viral Loads: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population.The Cochrane database of systematic reviews · 2021Pooled it
- Self-management interventions for adolescents living with HIV: a systematic review.BMC infectious diseases · 2021Pooled it
- Online Peer Support for Youth at Higher Risk of or Living with HIV: A Qualitative Content Analysis.AIDS and behavior · 2025Trial
- Increasing Sustained Viral Suppression Among Youth Living with HIV: A Randomized Controlled Trial of Stepped Care Intervention.AIDS and behavior · 2025Trial
- Strategies to Facilitate Service Utilization Among Youth at Risk for HIV: A Randomized Controlled Trial (ATN 149).AIDS and behavior · 2025Trial
- Technology-Based Interventions, with a Stepped Care Approach, for Reducing Sexual Risk Behaviors and Increasing PrEP Initiation Among Transgender and Gender Expansive Youth and Young Adults.AIDS and behavior · 2024Trial
- Rumination influences the relationship between trauma and depression over time among youth living with HIV.Journal of affective disorders · 2023Trial
- Trial
- A Social Media-Based Support Group for Youth Living With HIV in Nigeria (SMART Connections): Randomized Controlled Trial.Journal of medical Internet research · 2020Trial
- A Socioecological Perspective on Sexual Health Promotion Choices Among Youth At-Risk for and Living with HIV in Los Angeles and New Orleans.AIDS and behavior · 2026Article
- Disruptions of healthcare visits and viral suppression for people living with HIV during the COVID-19 pandemic in the US.BMC infectious diseases · 2025Article
- Longitudinal Viral Load Clustering for People With HIV Using Functional Principal Component Analysis.AIDS research and treatment · 2025Article
- Article
- Demographics of Youth With Newly Diagnosed Acute/Recent HIV Infection in Adolescent Trials Network 147: Early Treatment of Acute HIV Infection.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024Article
- Health System Responses to Address Treatment Gaps of Unsuppressed Adolescents on HIV Treatment in Public Primary Health Care Facilities in Windhoek, Namibia.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Exercise preferences for young people at-risk for and living with HIV: a short report.AIDS care · 2023Article
- The predictors of unsuppressed viremia among PLHIV: a cross-sectional study in Ghana.BMC public health · 2023Article
- Adolescents Living With or at Risk for HIV: A Pooled Descriptive Analysis of Studies From the Adolescent Medicine Trials Network for HIV/AIDS Interventions.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023Article
- Substance Use, Violence, and Sexual Risk Among Young Cis-Gender Women Placed at High-Risk for Human Immunodeficiency Virus Infection.AIDS and behavior · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAmong youth living with HIV (YLH) aged 12-24 years who have health care in the United States, only 30% to 40% are virally suppressed. YLH must achieve viral suppression in order to reduce the probability of infecting others as well as increasing the length and quality of their own life.
objectiveThis randomized controlled trial aimed to evaluate the efficacy of an Enhanced Standard Care condition (n=110) compared to an Enhanced Stepped Care intervention condition (n=110) to increase viral suppression among YLH aged 12-24 years with established infection (not acutely infected).
methodsYLH (N=220) who are not virally suppressed will be identified at homeless shelters, health clinics, and gay-identified community-based organizations in Los Angeles, CA, and New Orleans, LA. Informed consent will be obtained from all participants. YLH will be randomly assigned to one of two study conditions: Enhanced Standard Care, which includes standard clinical care plus an automated messaging and monitoring intervention (AMMI), or an Enhanced Stepped Care, which includes three levels of intervention (AMMI, Peer Support via social media plus AMMI, or Coaching plus Peer Support and AMMI). The primary outcome is viral suppression of HIV, and YLH will be assessed at 4-month intervals for 24 months. For the Enhanced Stepped Care intervention group, those who do not achieve viral suppression (via blood draw, viral load<200 copies/mL) at any 4-month assessment will "step up" to the next level of intervention. Secondary outcomes will be retention in care, antiretroviral therapy adherence, alcohol use, substance use, sexual behavior, and mental health symptoms.
resultsRecruitment for this study began in June 2017 and is ongoing. We estimate data collection to be completed by the end of 2020.
conclusionsThis is the first known application of an Enhanced Stepped Care intervention model for YLH. By providing the lowest level of intervention needed to achieve viral suppression, this model has the potential to be a cost-effective method of helping YLH achieve viral suppression and improve their quality of life.
trial registrationClinicalTrials.gov NCT03109431; https://clinicaltrials.gov/ct2/show/NCT03109431. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/10791.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.