ArticleeLife2019
Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency.Nature communications · 2025Article
- A comprehensive toolkit for protein localization and functional analysis in trypanosomatids.Open biology · 2025Article
- A polarized multicomponent foundation upholds ciliary central microtubules.Journal of molecular cell biology · 2025Article
- Identification of 30 transition fibre proteins in Trypanosoma brucei reveals a complex and dynamic structure.Journal of cell science · 2024Article
- Formation and function of multiciliated cells.The Journal of cell biology · 2024Review
- Structure, function and druggability of the African trypanosome flagellum.Journal of cellular physiology · 2022Review
- Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating.Molecular biology of the cell · 2021Article
- Central Apparatus, the Molecular Kickstarter of Ciliary and Flagellar Nanomachines.International journal of molecular sciences · 2021Review
- Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly.Nature communications · 2021Article
- A resource for improved predictions of Trypanosoma and Leishmania protein three-dimensional structure.PloS one · 2021Article
- Evolution of metabolic capabilities and molecular features of diplonemids, kinetoplastids, and euglenids.BMC biology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Most motile flagella have an axoneme that contains nine outer microtubule doublets and a central pair (CP) of microtubules. The CP coordinates the flagellar beat and defects in CP projections are associated with motility defects and human disease. The CP nucleate near a 'basal plate' at the distal end of the transition zone (TZ). Here, we show that the trypanosome TZ protein 'basalin' is essential for building the basal plate, and its loss is associated with CP nucleation defects, inefficient recruitment of CP assembly factors to the TZ, and flagellum paralysis. Guided by synteny, we identified a highly divergent basalin ortholog in the related Leishmania species. Basalins are predicted to be highly unstructured, suggesting they may act as 'hubs' facilitating many protein-protein interactions. This raises the general concept that proteins involved in cytoskeletal functions and appearing organism-specific, may have highly divergent and cryptic orthologs in other species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.