Evidence map›Paper›PMID 30810520›Full record

ArticleMicrobial genomics2019

Wave 2 strains of atypical Vibrio cholerae El Tor caused the 2009-2011 cholera outbreak in Papua New Guinea.

Andrew R Greenhill, Ankur Mutreja, Dieter Bulach, Matthew J Belousoff, Marinjho H Jonduo, Deirdre A Collins, Monalisa P Kas, Johanna Wapling, Torsten Seemann, Alice Lafana and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Atypical El TorMicrobiology spectrum · 2026
    Article
  2. Genomic analysis ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  3. Diarrhoeal disease surveillance in Papua New Guinea: findings and challenges.Western Pacific surveillance and response journal : WPSAR
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Andrew R Greenhill2​School of Health and Life Sciences, Federation University Australia, Churchill, Australia.
Ankur Mutreja3​Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Dieter Bulach5​Melbourne Bioinformatics, The University of Melbourne, Parkville, Australia.
Matthew J Belousoff6​Department of Microbiology, Monash University, Clayton, Australia.
Marinjho H Jonduo1​Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Deirdre A Collins1​Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Monalisa P Kas1​Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Johanna Wapling1​Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Torsten Seemann5​Melbourne Bioinformatics, The University of Melbourne, Parkville, Australia.
Alice Lafana1​Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Gordon Dougan3​Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Mark V Brown8​School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia.
Paul F Horwood1​Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Papua New Guinea Institute of Medical Research · PGMonash University · AUWellcome Sanger Institute · GBAustralian Institute of Tropical Health and Medicine · AUFederation University · AUMelbourne Bioinformatics · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vibrio cholerae is the causative agent of cholera, a globally important human disease for at least 200 years. In 2009-2011, the first recorded cholera outbreak in Papua New Guinea (PNG) occurred. We conducted genetic and phenotypic characterization of 21 isolates of V. cholerae, with whole-genome sequencing conducted on 2 representative isolates. The PNG outbreak was caused by an atypical El Tor strain harbouring a tandem repeat of the CTX prophage on chromosome II. Whole-genome sequence data, prophage structural analysis and the absence of the SXT integrative conjugative element was indicative that the PNG isolates were most closely related to strains previously isolated in South-East and East Asia with affiliations to global wave 2 strains. This finding suggests that the cholera outbreak in PNG was caused by an exotic (non-endemic) strain of V. cholerae that originated in South-East Asia.

Indexed as

CholeraDisease OutbreaksGenetic VariationGenome, BacterialHumansPapua New GuineaProphagesSequence Analysis, DNAVibrio choleraeWhole Genome SequencingAsiacholeraO1OceaniaPacificV. Cholerae

Identifiers

PMID30810520
PMCPMC6487313
OpenAlexW2917900264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.