Evidence map›Paper›PMID 30810440›Full record

ArticlePlatelets2020

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion.

Anh T P Ngo, Jawaad Sheriff, Anne D Rocheleau, Matthew Bucher, Kendra R Jones, Anna-Liisa I Sepp, Lisa E Malone, Amanda Zigomalas, Alina Maloyan, Wadie F Bahou and 3 more

Open access · greenAbstract read
In one paragraph

Article in Platelets, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. The Signaling Pathway of the ADP Receptor P2YInternational journal of molecular sciences · 2023
    Review
  4. Article
  5. Platelets in the neonate: Not just a small adult.Research and practice in thrombosis and haemostasis · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Device-Induced Hemostatic Disorders in Mechanically Assisted Circulation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Anh T P NgoDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID https://orcid.org/0000-0002-2179-6584
Jawaad SheriffDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Anne D RocheleauDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Matthew BucherDepartment of Obstetrics and Gynecology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
Kendra R JonesDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Anna-Liisa I SeppDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Lisa E MaloneDivision of Hematology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.
Amanda ZigomalasDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Alina MaloyanDepartment of Obstetrics and Gynecology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.ORCID https://orcid.org/0000-0002-7309-5026
Wadie F BahouDivision of Hematology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.
Danny BluesteinDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Owen J T McCartyDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Kristina M HaleyThe Hemophilia Center, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USStony Brook University · US

Funding

Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5M
Multiscale Modeling of Blood Flow and Platelet Mediated ThrombosisU01HL131052 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BLUESTEIN, DANNY · 2016 to 2020
$3.6M
Platelet Systems Biology in Health and DiseaseR01HL119096 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAHOU, WADIE F · 2015 to 2019
$3.5M
Molecular characterization of biliverdin IXbeta reductaseR01HL153144 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAHOU, WADIE F · 2021 to 2024
$2.0M
Multiscale modeling of blood flow and clotting in cardiovascular devicesR21HL096930 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BLUESTEIN, DANNY · 2011 to 2012
$421k
NHLBI NIH HHS R01 HL101972NHLBI NIH HHS R01 HL119096NHLBI NIH HHS R01 HL153144NHLBI NIH HHS R21 HL096930NHLBI NIH HHS U01 HL131052
6 · The paper itself

Abstract

Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neonatal platelet response downstream of the hemostatic platelet agonists thrombin and adenosine diphosphate (ADP). Thrombin activates platelets via the protease-activated receptors (PARs) 1 and 4, whereas ADP signals via the receptors P2Y

Indexed as

Adenosine DiphosphateAdenosine TriphosphateBiological TransportBiomarkersBlood CoagulationBlood PlateletsCytoplasmic GranulesHumansInfant, NewbornIntegrinsPlatelet ActivationPlatelet AggregationShear StrengthThrombinAdenosine DiphosphateAdenosine TriphosphateBiomarkersIntegrinsThrombinHemostasisneonatal hematologyplateletprotease-activated receptors

Identifiers

PMID30810440
PMCPMC6711836
OpenAlexW2917750214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.