Evidence map›Paper›PMID 30810065›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Short-duration hyperoxia causes genotoxicity in mouse lungs: protection by volatile anesthetic isoflurane.

Venkatesh Kundumani-Sridharan, Jaganathan Subramani, Somasundaram Raghavan, Guru P Maiti, Cade Owens, Trevor Walker, John Wasnick, Steven Idell, Kumuda C Das

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Autophagy, TERT, and mitochondrial dysfunction in hyperoxia.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Venkatesh Kundumani-SridharanDepartment of Internal Medicine, Texas Tech University Health Sciences Center , Lubbock, Texas.
Jaganathan SubramaniDepartment of Internal Medicine, Texas Tech University Health Sciences Center , Lubbock, Texas.
Somasundaram RaghavanDepartment of Internal Medicine, Texas Tech University Health Sciences Center , Lubbock, Texas.
Guru P MaitiOklahoma Medical Research Foundation , Oklahoma City, Oklahoma.
Cade OwensDepartment of Anesthesiology, Texas Tech University Health Sciences Center , Lubbock, Texas.
Trevor WalkerDepartment of Anesthesiology, Texas Tech University Health Sciences Center , Lubbock, Texas.
John WasnickDepartment of Anesthesiology, Texas Tech University Health Sciences Center , Lubbock, Texas.
Steven IdellDepartment of Cellular and Molecular Biology, Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler , Tyler, Texas.
Kumuda C DasDepartment of Internal Medicine, Texas Tech University Health Sciences Center , Lubbock, Texas.ORCID 0000-0001-7734-3368
Texas Tech University · USOklahoma Medical Research Foundation · USThe University of Texas Health Science Center at Tyler · US

Funding

Amelioration of Mitochondrial Dysfunction by Thioredoxin in HyperoxiaR01HL130061 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI DAS, KUMUDA C · 2016 to 2018
$1.5M
NHLBI NIH HHS R01 HL130061
6 · The paper itself

Abstract

High concentrations of oxygen (hyperoxia) are routinely used during anesthesia, and supplemental oxygen is also administered in connection with several other clinical conditions. Although prolonged hyperoxia is known to cause acute lung injury (ALI), whether short-duration hyperoxia causes lung toxicity remains unknown. We exposed mice to room air (RA or 21% O

Indexed as

Acute Lung InjuryDNA DamageHyperoxiaLungAnimalsCell LineIsofluraneMaleMiceNADPH OxidasesSuperoxidesIsofluraneNADPH OxidasesSuperoxidesDNA damageDNA repairhyperoxiaisofluranelung

Identifiers

PMID30810065
PMCPMC6589579
OpenAlexW2915642944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.