ArticleEnvironmental microbiology reports2019
Cyanophage MazG is a pyrophosphohydrolase but unable to hydrolyse magic spot nucleotides.
Article in Environmental microbiology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
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- Characterization and Genomic Analysis of a Lytic Vibriophage vB_VneS_S3 of Infecting Vibrio neocaledonicus.Current microbiology · 2025Article
- Profiling the interplay and coevolution ofMicrobiology spectrum · 2024Article
- Genome sequences of the firstMicrobial genomics · 2024Article
- Coordinated transcriptional response to environmental stress by a Synechococcus virus.The ISME journal · 2024Article
- Four additional natural 7-deazaguanine derivatives in phages and how to make them.Nucleic acids research · 2023Article
- Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG fromFrontiers in microbiology · 2023Article
- Metagenomics of Virus Diversities in Solid-State Brewing Process of Traditional Chinese Vinegar.Foods (Basel, Switzerland) · 2022Article
- A NovelMicrobiology spectrum · 2022Article
- A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics.Infectious diseases of poverty · 2022Article
- Morphological and Genetic Characterization ofViruses · 2022Article
- Newly identified HMO-2011-type phages reveal genomic diversity and biogeographic distributions of this marine viral group.The ISME journal · 2022Article
- Isolation and Characterization of a Novel Cyanophage Encoding Multiple Auxiliary Metabolic Genes.Viruses · 2022Article
- A Novel and Ubiquitous Marine Methylophage Provides Insights into Viral-Host Coevolution and Possible Host-Range Expansion in Streamlined Marine Heterotrophic Bacteria.Applied and environmental microbiology · 2022Article
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- Genetic engineering of marine cyanophages reveals integration but not lysogeny in T7-like cyanophages.The ISME journal · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Bacteriophage possess a variety of auxiliary metabolic genes of bacterial origin. These proteins enable them to maximize infection efficiency, subverting bacterial metabolic processes for the purpose of viral genome replication and synthesis of the next generation of virion progeny. Here, we examined the enzymatic activity of a cyanophage MazG protein - a putative pyrophosphohydrolase previously implicated in regulation of the stringent response via reducing levels of the central alarmone molecule (p)ppGpp. We demonstrate, however, that the purified viral MazG shows no binding or hydrolysis activity against (p)ppGpp. Instead, dGTP and dCTP appear to be the preferred substrates of this protein, consistent with a role preferentially hydrolysing deoxyribonucleotides from the high GC content host Synechococcus genome. This showcases a new example of the fine-tuned nature of viral metabolic processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.