ArticleJournal of child psychology and psychiatry, and allied disciplines2019
Longitudinal pathways linking family risk, neural risk processing, delay discounting, and adolescent substance use.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peer Delivered Episodic Future Thinking to Improve MOUD Treatment Engagement Among Returning Citizens - A Randomized Controlled Trial
Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A systematic review and meta-analysis of delay discounting and cannabis use.Experimental and clinical psychopharmacology · 2021Pooled it
- A web-based episodic specificity and future thinking session modulates delay discounting in cannabis users.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Trial
- Identifying significant environmental predictors of change in delay discounting among adolescents in the Adolescent Brain Cognitive Development Study.Experimental and clinical psychopharmacology · 2026Article
- Intertemporal Decision-Making, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults With a Family History of Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- Household Adversity, Day to Day Experiences, and Birth/Pregnancy Complications are Associated with Delay Discounting: Findings from the Adolescent Brain Cognitive Development Study.Research on child and adolescent psychopathology · 2026Article
- Structural stressors, neurocognition in reward-related decision making and substance use risk in Puerto Rican early adolescents at two sites: study design.Frontiers in public health · 2026Observational
- A systematic review and meta-analysis of the impact of environmental disadvantage on youth delayed reward discounting.Development and psychopathology · 2025Article
- Delay Discounting, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults with a Family History of Alcohol Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Will you precrastinate? Sensitivity to potential performance costs and effort in chronic cannabis users and non-users.Psychological research · 2025Article
- Article
- Biotin Mitigates Alcohol Withdrawal-Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats.Neuropsychopharmacology reports · 2025Article
- Environmental Support Moderates the association of Socioeconomic Distress and Delay Discounting across Adolescence.Journal of youth and adolescence · 2024Article
- Delay discounting is associated with addiction and mental health measures while controlling for health behaviors and health barriers in a large US sample.Addictive behaviors reports · 2024Article
- Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Implementation of a Risk Reduction Protocol in Youth Violence Research.Ethics & behavior · 2024Article
- Development in uncertain contexts: An ecologically informed approach to understanding decision-making during adolescence.Cognitive, affective & behavioral neuroscience · 2023Review
- Religious affiliation protects against alcohol/substance use initiation: A prospective study among healthy adolescents.Journal of adolescence · 2023Article
- Developmental trajectories of delay discounting from childhood to young adulthood: longitudinal associations and test-retest reliability.Cognitive psychology · 2022Article
- Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers.Psychopharmacology · 2022Article
- Identification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCurrent theories in neuroscience emphasize the crucial role of individual differences in the brain contributing to the development of risk taking during adolescence. Yet, little is known about developmental pathways through which family risk factors are related to neural processing of risk during decision making, ultimately contributing to health risk behaviors. Using a longitudinal design, we tested whether neural risk processing, as affected by family multi-risk index, predicted delay discounting and substance use.
methodOne hundred and fifty-seven adolescents (aged 13-14 years at Time 1, 52% male) were assessed annually three times. Family multi-risk index was measured by socioeconomic adversity, household chaos, and family risk-taking behaviors. Delay discounting was assessed by a computerized task, substance use by questionnaire data, and risk-related neural processing by blood-oxygen-level-dependent (BOLD) responses in the amygdala during a lottery choice task.
resultsFamily multi-risk index at Time 1 was related to adolescent substance use at Time 3 (after controlling for baseline substance use) indirectly through heightened amygdala sensitivity to risks and greater delay discounting.
conclusionsOur results elucidate the crucial role of neural risk processing in the processes linking family multi-risk index and the development of substance use. Furthermore, risk-related amygdala activation and delay discounting are important targets in the prevention and treatment of substance use among adolescents growing up in high-risk family environments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.