SynthesisBrain imaging and behavior2020
Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.
Synthesis in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Distinct brain activation patterns linked to clinical symptoms during hand grasping in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Functional and Structural Connectivity Correlates of Axial Symptom Outcomes After Pallidal Deep Brain Stimulation in Parkinson's Disease.Brain sciences · 2025Article
- Rehabilitation Response in Tremor- and Non-Tremor-Dominant Parkinson Disease: A Task-fMRI Study.Brain and behavior · 2024Article
- Reorganization of motor network in patients with Parkinson's disease after deep brain stimulation.CNS neuroscience & therapeutics · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Functional brain controllability in Parkinson's disease and its association with motor outcomes after deep brain stimulation.Frontiers in neuroscience · 2024Article
- Structural MRI substrate of long-duration response to levodopa in Parkinson's disease: an exploratory study.Journal of neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate factors affecting the pattern of motor brain activation reported in people with Parkinson's (PwP), aiming to differentiate disease-specific features from treatment effects.
methodsA co-ordinate-based-meta-analysis (CBMA) of functional motor neuroimaging studies involving patients with Parkinson's (PwP), and healthy controls (HC) identified 126 suitable articles. The experiments were grouped based on subject feature, medication status (onMed/offMed), deep brain stimulation (DBS) status (DBSon/DBSoff) and type of motor initiation.
resultsHC and PwP shared similar neural networks during upper extremity motor tasks but with differences of reported frequency in mainly bilateral putamen, insula and ipsilateral inferior parietal and precentral gyri. The activation height was significantly reduced in the bilateral putamen, left SMA, left subthalamus nucleus, right thalamus and right midial global pallidum in PwP
conclusionWe describe a consistent disease-specific pattern of putaminal hypoactivation during motor tasks that appears reversed by dopamine replacement. Inconsistent reports of altered SMA/pre-SMA activation can be explained by task- and medication-specific variation in intention. Moreover, SMA activity was reduced during STN-DBS, while dopamine-induced hyperactivation of SMA which might underpin hyperdynamic L-dopa related overcompensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.