Evidence map›Paper›PMID 30809725›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019

Effects of a 3-month weight-bearing and resistance exercise training on circulating osteogenic cells and bone formation markers in postmenopausal women with low bone mass.

L Pasqualini, S Ministrini, R Lombardini, F Bagaglia, R Paltriccia, R Pippi, L Collebrusco, E Reginato, E Sbroma Tomaro, E Marini and 4 more

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03195517 (Effects of a 3-month Weight-bearing and Resistance Exercise Training on Circulating Osteoprogenitor Cells and Bone Formation Markers in Postmenopausal Women With Low Bone Mass.), which is not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03195517 nacompletednot on this map

Effects of a 3-month Weight-bearing and Resistance Exercise Training on Circulating Osteoprogenitor Cells and Bone Formation Markers in Postmenopausal Women With Low Bone Mass.

TypeinterventionalSponsorUniversity Of PerugiaRan2015 to 2016Enrolled33ConditionsOsteopenia, Bone Turnover Markers, Quality of LifeArmsPhysical exercise
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  7. Effects of weighted vest on bone health and body fat in middle-aged and older adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

L PasqualiniSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
S MinistriniSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy. stefano.mns@gmail.com.ORCID http://orcid.org/0000-0003-4358-6411
R LombardiniSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
F BagagliaSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
R PaltricciaSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
R PippiHealthy Lifestyle Institute CURIAMO, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
L CollebruscoRehabilitation Unit, National Health Service of Umbria, Perugia, Italy.
E ReginatoHealthy Lifestyle Institute CURIAMO, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
E Sbroma TomaroHealthy Lifestyle Institute CURIAMO, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
E MariniSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
M D'AbbondanzaSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
A M ScarponiMedicina Interna, Azienda Ospedaliera "S.M. della Misericordia", Perugia, Italy.
P De FeoHealthy Lifestyle Institute CURIAMO, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
M PirroSezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
University of Perugia · ITAzienda Ospedaliera di Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is a health issue in postmenopausal women. Physical activity is recommended in these subjects, since it has positive effects on bone mass. Cellular mechanisms underlying this effect are still unclear. Osteogenic cells, released after physical exertion, could be a key factor in exercise-induced bone formation.

introductionThe aim of our research was to explore if a weight-bearing and resistance exercise program could positively affect circulating osteogenic cells (OCs), markers of bone formation and quality of life (QoL) in osteopenic postmenopausal women.

methodsWe recruited 33 postmenopausal women with a T-score at lumbar spine or femoral neck between - 1 and - 2.5 SD. Anthropometric and fitness parameters, bone-remodeling markers, OCs, and QoL were evaluated at the time of enrolment, after 1-month run-in period, and after 3 months of weight-bearing and resistance exercise.

resultsAfter 3 months of training, the pro-collagen type 1 N-terminal peptide (P1NP) and the number of OCs were significantly increased, with no significant increase of the type 1 collagen cross-linked C-telopeptide (sCTX). We also observed a significant increase in body height, one-repetition maximum (1RM) on the pull-down lat machine and leg press, and mean VO

conclusionsThe exercise program we trialed is able to increase the markers of bone formation and the commitment of immature OCs with no significant increase in the markers of bone resorption. Our results confirm that combined weight-bearing and resistance physical activity is an effective tool to improve QoL of postmenopausal women with low bone mass.

trial registrationNCT03195517.

Indexed as

AnthropometryBiomarkersBody CompositionBody HeightBone DensityBone RemodelingFemaleFemur NeckHumansLumbar VertebraeMiddle AgedOsteoblastsOsteogenesisOsteoporosis, PostmenopausalQuality of LifeResistance TrainingBiomarkersBone-remodeling markersCirculating osteogenic cellsHealth-related quality of lifePostmenopausal healthSclerostinWeight-bearing physical activity

Identifiers

PMID30809725
OpenAlexW2915400346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.