ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Actual memory as a mediator of the amyloid-subjective cognitive decline relationship.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dissociable Mechanisms Underlie Differences Between Memory and Metamemory in Older Adults: The Differentiating Role of Anxiety and Depression Symptoms.Hippocampus · 2026Article
- The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging.Scientific data · 2025Article
- Self- and study partner-reported cognitive decline in older adults without dementia: The role of α-synuclein and amyloid biomarkers in the Alzheimer's Disease Neuroimaging Initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Role of Awareness of Age-Related Change in the Longitudinal Association between Pain and Physical Activity.International journal of aging & human development · 2024Article
- Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline.Frontiers in psychiatry · 2023Article
- Metacognition, cortical thickness, and tauopathy in aging.Neurobiology of aging · 2022Article
- Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint.Alzheimer's research & therapy · 2022Article
- Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer's Disease.Frontiers in neuroscience · 2022Article
- Subjective Cognitive Decline Is More Accurate When Metamemory Is Better.Frontiers in aging neuroscience · 2022Article
- Exploring the Necessity of Psychological Rounds and Psychological Interventions in General Hospitals in the Post-COVID-19 Period.Frontiers in psychology · 2022Article
- Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease.Molecular neurodegeneration · 2020Review
- Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD · 2020Article
- An approach to classifying subjective cognitive decline in community-dwelling elders.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Targeting age-related differences in brain and cognition with multimodal imaging and connectome topography profiling.Human brain mapping · 2019Article
- Recent contributions to the field of subjective cognitive decline in aging: A literature review.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionAmyloid pathology in cognitively normal adults is associated with subjective cognitive decline, potentially reflecting awareness of Alzheimer's-related memory deficits. To clarify the mechanism underlying this relationship, we used mediational analyses to determine the role of depression, anxiety, and actual memory performance.
methodsTo assess amyloid deposition, we imaged 85 cognitively normal adults with florbetapir positron emission tomography imaging. Subjective cognitive decline was measured using a multidimensional instrument that assessed seven subjective memory domains. Mediational measures included assessments of actual memory performance (current and retrospective longitudinal change), depression, and anxiety.
resultsThe relationship between amyloid and subjective cognitive decline was mediated by poorer memory performance and greater retrospective memory decline, not depression or anxiety. The mediational roles were significant for domains associated with memory function and memory-related anxiety. DISCUSSION: In individuals harboring amyloid, self-reported beliefs of declining memory likely indicate early self-awareness of actual worsening function rather than depression or anxiety.
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