Evidence map›Paper›PMID 30809549›Full record

ArticleBioMed research international2019

Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice.

Rariane Silva de Lima, Juliane Cristina de Souza Silva, Cintia Taniguti Lima, Leandro Ezequiel de Souza, Maikon Barbosa da Silva, Marina Gazzano Baladi, Maria Claudia Irigoyen, Silvia Lacchini

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. ATPflugers Archiv : European journal of physiology · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Vasorelaxant Effect ofMolecules (Basel, Switzerland) · 2022
    Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rariane Silva de LimaDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil.ORCID 0000-0002-6455-9239
Juliane Cristina de Souza SilvaDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Cintia Taniguti LimaDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Leandro Ezequiel de SouzaHypertension Unit, Heart Institute, University of São Paulo Medical School, Brazil.
Maikon Barbosa da SilvaHypertension Unit, Heart Institute, University of São Paulo Medical School, Brazil.
Marina Gazzano BaladiDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Maria Claudia IrigoyenHypertension Unit, Heart Institute, University of São Paulo Medical School, Brazil.
Silvia LacchiniDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil.ORCID 0000-0002-7937-8473
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin II plays important functions in cardiovascular system mediating actions leading to inflammatory responses such as activation of VSMC in order to produce ROS, inflammatory cytokines, chemokines, and adhesion molecules. Changes in angiotensin II production could stimulate the recruitment and activation of myeloid cells initiating local inflammatory response without effect on BP. We aimed to verify if angiotensin II induces an inflammatory response in the aorta and if it correlates with variations in BP. C57Bl/6 mice treated with saline solution (0.9%, control group) or angiotensin II (30ng/kg, Ang II group) were used. BP and HR levels were measured. Immunohistochemistry for IL1-

Indexed as

ActinsAngiotensin IIAnimalsAortaBlood PressureCardiovascular DiseasesGene Expression RegulationHumansInterleukin-1betaLeukocyte Common AntigensMiceMuscle, Smooth, VascularNitric Oxide Synthase Type IISaline SolutionTransforming Growth Factor betaActinsAngiotensin IIInterleukin-1betaLeukocyte Common AntigensNitric Oxide Synthase Type IINos2 protein, mousePtprc protein, mouseSaline SolutionTransforming Growth Factor beta

Identifiers

PMID30809549
PMCPMC6369478
OpenAlexW2913476289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.