Evidence map›Paper›PMID 30809532›Full record

ArticleBioMed research international2019

Bioinformatics Analysis Reveals the Altered Gene Expression of Patients with Postmenopausal Osteoporosis Using Liuweidihuang Pills Treatment.

Rui Gong, Shan Ren, Menghui Chen, Yanli Wang, Guoliang Zhang, Lijuan Shi, Cuizhao Zhang, Ruihong Su, Yukun Li

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Liuwei Dihuang Prevents Human Umbilical Vein Endothelial Cells SenescenceCombinatorial chemistry & high throughput screening · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Tomatidine Alleviates Osteoporosis by Downregulation of p53.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rui GongHebei Medical University Endocrine Research Institute, China.
Shan RenDepartment of ICU, Hebei General Hospital, China.
Menghui ChenDepartment of Cardiothoracic Surgery, The Third Hospital of Shijiazhuang, China.
Yanli WangObstetrics and Gynecology, The Third Hospital of Shijiazhuang, China.
Guoliang ZhangDepartment of Cardiothoracic Surgery, The Third Hospital of Shijiazhuang, China.
Lijuan ShiDepartment of Endocrinology, The Third Hospital of Shijiazhuang, China.
Cuizhao ZhangDepartment of Laboratory, The Third Hospital of Shijiazhuang, China.
Ruihong SuDepartment of Laboratory, The Third Hospital of Shijiazhuang, China.
Yukun LiDepartment of Endocrinology, The Third Affiliated Hospital of Hebei Medical University, China.ORCID 0000-0002-7440-672X
Hebei Medical University · CNHebei General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis (PMOP), as well as its associated increased risk for fragility fracture, is one of the most disabling consequences of aging in women. This present study aimed to identify candidate genes that involve pathogenesis of PMOP and the therapeutic mechanism of Liuweidihuang (LWDH) pills on PMOP. We integrated microarray datasets of PMOP derived from the Gene Expression Omnibus (GEO) to screen differentially expressed genes (DEGs) between PMOP and normal controls as well as patients with PMOP and patients after treatment of LWDH pills. GO and KEGG enrichment analysis for DEGs were performed. The shared DEGs, associated with both the pathogenesis of PMOP and the therapeutic mechanism of LWDH, were further analyzed by protein-protein interaction (PPI) network. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to verify the DEGs obtained by our integrated analysis. Compared with normal controls, 1732 DEGs in PMOP were obtained with

Indexed as

Computational BiologyActivating Transcription Factor 2Cytoskeletal ProteinsDrugs, Chinese HerbalF-Box-WD Repeat-Containing Protein 7Gene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMembrane ProteinsOsteoporosis, PostmenopausalProtein BindingProtein Interaction MapsRetinoblastoma-Binding Protein 4Signal TransductionActivating Transcription Factor 2ATF2 protein, humanCytoskeletal ProteinsDrugs, Chinese HerbalF-Box-WD Repeat-Containing Protein 7FBXW7 protein, humanLiuwei Dihuang DecoctionliuweiwulingMembrane ProteinsradixinRBBP4 protein, humanRetinoblastoma-Binding Protein 4

Identifiers

PMID30809532
PMCPMC6369488
OpenAlexW2914187223

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.