ArticleJournal of epilepsy research2018
Validity of the Liverpool Adverse Events Profile as a Screening Tool for Detecting Comorbid Depression or Anxiety Disorder in People with Epilepsy.
Article in Journal of epilepsy research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Treatment Response to Antiseizure Medications in People With Newly Diagnosed Focal Epilepsy.JAMA neurology · 2025Observational
- Validating the Traditional Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) in Hong Kong.Frontiers in neurology · 2025Article
- Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy.CNS drugs · 2023Article
- Efficacy, Retention and Tolerability of Everolimus in Patients with Tuberous Sclerosis Complex: A Survey-Based Study on Patients' Perspectives.CNS drugs · 2021Article
- Systematic Literature Review of Psychiatric Comorbidities in Adults with Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe Liverpool adverse events profile (LAEP) is useful for detecting and monitoring the adverse effects of antiepileptic drugs (AEDs) and contains items related to symptoms of depression or anxiety. This study evaluated the usefulness of the LAEP for detecting comorbid depression or anxiety disorder in people with epilepsy (PWE).
methodsPWE, aged from 18 to 70 years and who took AEDs for at least 1 year, were included. They completed the Korean version of the LAEP (K-LAEP) to detect the adverse effects of AEDs and the mini international neuropsychiatric interview-plus version 5.0.0 (MINI) to identify major depressive disorder (MDD) and generalized anxiety disorder (GAD). We validated the K-LAEP as a screening tool for coexisting MDD or GAD in PWE. Receiver operating character (ROC) curve analyses were used to measure the appropriateness of cutoff scores for the total and item K-LAEP scores for detecting MDD or GAD.
resultsThe study enrolled 150 PWE. According to the MINI, 30 PWE (20.0%) had MDD and 26 (17.3%) had GAD. Cronbach's α coefficient of the K-LAEP was 0.939. For the total K-LAEP score, cutoff scores of 40 and 43 could detect MDD and GAD, respectively. For the K-LAEP item score, a cutoff of five could detect MDD or GAD.
conclusionsThe K-LAEP is a valid screening tool for detecting MDD and GAD in PWE. A high LAEP score suggests comorbid psychiatric disorders, which need further specific evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.