ArticleInternational journal of ophthalmology2019
Th lymphocyte subsets in patients with Vogt-Koyanagi-Harada disease.
Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Immunological Profiling of Leukocyte Subset Proportions and Novel Blood Biomarkers in the Acute Phase of Ocular Sarcoidosis and Vogt-Koyanagi-Harada Disease: An Exploratory Pilot Study.International journal of molecular sciences · 2026Article
- Efficacy of Tumor Necrosis Factor-α Inhibitor Adalimumab in Chronic Recurrent Vogt-Koyanagi-Harada Disease.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Review
- Ocular and Serum Profiles of Inflammatory Molecules Associated With Retinitis Pigmentosa.Translational vision science & technology · 2024Article
- Classification of Peripheral Blood Leukocyte Phenotypes and Serum Cytokines in Vogt-Koyanagi-Harada Disease before and after Glucocorticoid Therapy.Journal of clinical medicine · 2023Article
- Autoimmune uveitis in Behçet's disease and Vogt-Koyanagi-Harada disease differ in tissue immune infiltration and T cell clonality.Clinical & translational immunology · 2023Article
- Insights gained from single-cell analysis of immune cells in tofacitinib treatment of Vogt-Koyanagi-Harada disease.JCI insight · 2022Article
- Vogt-Koyanagi-Harada disease: the step-by-step approach to a better understanding of clinicopathology, immunopathology, diagnosis, and management: a brief review.Journal of ophthalmic inflammation and infection · 2022Review
- Case report: Bilateral panuveitis resembling Vogt-Koyanagi-Harada disease after second dose of BNT162b2 mRNA COVID-19 vaccine.Frontiers in immunology · 2022Article
- Tregs in Autoimmune Uveitis.Advances in experimental medicine and biology · 2021Article
- Immune Phenotyping of Patients With Acute Vogt-Koyanagi-Harada Syndrome Before and After Glucocorticoids Therapy.Frontiers in immunology · 2021Article
- Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis.Journal of immunology research · 2021Review
- Serum Metabolomic Profiling of Patients with Non-Infectious Uveitis.Journal of clinical medicine · 2020Article
- A case presentation of an IgA nephropathy patient with Vogt-Koyanagi-Harada syndrome.BMC nephrology · 2020Article
- Article
- Integrated Analysis of Key Pathways and Drug Targets Associated With Vogt-Koyanagi-Harada Disease.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess helper T (Th) lymphocyte subset balance in patients with Vogt-Koyanagi-Harada (VKH) disease.
methodsSixty-eight active VKH patients and seventy-two inactive VKH patients were included in this study. One hundred healthy individuals served as controls. Peripheral blood was obtained from VKH patients and healthy controls. Th lymphocyte subsets were analyzed by flow cytometry. Plasma concentration of interleukin (IL)-17, IL-10, transforming growth factor (TGF)-β, IL-23 and IL-6 was examined by enzyme-linked immunosorbent assay (ELISA).
resultsVKH patients with active uveitis had significantly higher percentages of both Th1 and Th17 cells and lower percentages of regulatory T (Treg) cells as compared with inactive VKH patients and healthy controls. Th1/Th2 and Th17/Treg ratios were also significantly elevated in active VKH patients. The percentages of Th1, Th17 and Treg cells and the Th1/Th2, Th17/Treg ratio did not differ between inactive VKH patients and healthy controls. There was no difference concerning the percentage of Th2 cells among all the groups. VKH patients with active uveitis showed an elevated level of peripheral Th17 related cytokines levels (TGF-β, IL-6, IL-23, and IL-17) and a decreased level of Treg related cytokines (IL-10) compared with inactive VKH patients and healthy controls. Inactive VKH patients showed no differences in peripheral Th17 related cytokines (TGF-β, IL-6, IL-23, and IL-17) and Treg related cytokines (IL-10) levels compared with healthy controls.
conclusionTh1 and Th17 cells are significantly increased and Treg cells significantly decreased in active VKH compared with inactive VKH or healthy controls. Therefore, Th lymphocyte subset analysis may serve as a disease biomarker for VKH.
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