Evidence map›Paper›PMID 30809408›Full record

ArticleCase reports in pathology2019

Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile.

Caroline Koopmansch, Calliope Maris, Pieter Demetter, Jean Van de Stadt, Alain Hendlisz, Nicky D'Haene, Jean-Christophe Noël

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Caroline KoopmanschDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, Belgium.ORCID 0000-0002-4908-751X
Calliope MarisDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, Belgium.
Pieter DemetterDepartment of Pathology, Jules Bordet Institute, Free University of Brussels (ULB), Brussels, Belgium.
Jean Van de StadtDepartment of Digestive Surgery, Erasme University Hospital, Free University of Brussels (ULB), Brussels, Belgium.
Alain HendliszDigestive Oncology Unit, Medicine Department, Jules Bordet Institute, Free University of Brussels (ULB), Brussels, Belgium.
Nicky D'HaeneDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, Belgium.
Jean-Christophe NoëlDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, Belgium.
Institut Jules Bordet · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it. In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma. In addition, using the next generation sequencing (NGS) technique, we have demonstrated TP53 mutation in the invasive component but not in the associated DIN-like lesion, where p53 immunohistochemical expression was restricted to basal layers.

Identifiers

PMID30809408
PMCPMC6369487
OpenAlexW2913815987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.