Evidence map›Paper›PMID 30809231›Full record

ArticleFrontiers in immunology2019

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8

Markus Zwick, Thomas Ulas, Yi-Li Cho, Christine Ried, Leonie Grosse, Charlotte Simon, Caroline Bernhard, Dirk H Busch, Joachim L Schultze, Veit R Buchholz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Markus ZwickFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Thomas UlasLife and Medical Sciences Institute, Bonn, Germany.
Yi-Li ChoInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
Christine RiedFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Leonie GrosseFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Charlotte SimonFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Caroline BernhardFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
Joachim L SchultzeLife and Medical Sciences Institute, Bonn, Germany.
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
Susanne StutteFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Thomas BrockerFaculty of Medicine, Biomedical Center (BMC), Institute for Immunology, LMU Munich, Planegg-Martinsried, Germany.
Ludwig-Maximilians-Universität München · DEInstitute of Medical Microbiology and Hygiene · DEGerman Center for Neurodegenerative Diseases · DEUrologische Klinik München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various autoimmune diseases in model systems. We have generated mice deficient for

Indexed as

AnimalsAntigen PresentationApoptosisBcl-2-Like Protein 11CD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCells, CulturedCross-PrimingDendritic CellsHomeostasisLymphocyte ActivationMiceMice, KnockoutPhosphoprotein PhosphatasesBcl-2-Like Protein 11Phosphoprotein PhosphatasesPpef2 protein, mouseapoptosisCD8 T cell primingcross-presentationDC-maturationdendritic cellsimmune homeostasis

Identifiers

PMID30809231
PMCPMC6379467
OpenAlexW2949164970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.