Evidence map›Paper›PMID 30809229›Full record

ArticleFrontiers in immunology2019

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.

Julia Roider, Abigail Ngoepe, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Thumbi Ndung'u, Henrik Kløverpris, Philip Goulder, Alasdair Leslie

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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  11. Emerging patterns of regulatory T cell function in tuberculosis.Clinical and experimental immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Julia RoiderAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Abigail NgoepeAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Maximilian MuenchhoffDepartment of Virology, Max von Pettenkofer Institute, Ludwig-Maximilians-University Munich, Munich, Germany.
Emily AdlandDepartment of Paediatrics, Peter Medawar Building for Pathogen Research, Oxford University, Oxford, United Kingdom.
Andreas GrollFaculty of Statistics, TU Dortmund University, Dortmund, Germany.
Thumbi Ndung'uAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Henrik KløverprisAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Philip GoulderDepartment of Paediatrics, Peter Medawar Building for Pathogen Research, Oxford University, Oxford, United Kingdom.
Alasdair LeslieAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
University of Oxford · GBAfrica Health Research Institute · ZALudwig-Maximilians-Universität München · DETU Dortmund University · DEUniversity College London · GBUniversity of KwaZulu-Natal · ZA

Funding

Maximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI133673Wellcome Trust 202485/Z/16/Z
6 · The paper itself

Abstract

Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulatory T-cells (T

Indexed as

Lymphocyte ActivationSignal TransductionAntiretroviral Therapy, Highly ActiveBiomarkersCD4 Lymphocyte CountDisease ProgressionHIV-1HIV InfectionsHomeostasisHumansImmunologic MemoryT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsViral LoadBiomarkershomeostatic signalingIL-10IL-7immune activation (IA)immune regulationpediatric HIV-infectionpediatric slow progressionregulatory T cells (Treg)

Identifiers

PMID30809229
PMCPMC6379343
OpenAlexW2913509051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.