Evidence map›Paper›PMID 30809187›Full record

ArticleFrontiers in neurology2019

Feasibility of Human Neural Stem Cell Transplantation for the Treatment of Acute Subdural Hematoma in a Rat Model: A Pilot Study.

Shoji Yokobori, Kazuma Sasaki, Takahiro Kanaya, Yutaka Igarashi, Ryuta Nakae, Hidetaka Onda, Tomohiko Masuno, Satoshi Suda, Kota Sowa, Masataka Nakajima and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Recent Advances in Cell-Based Therapies for Ischemic Stroke.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Shoji YokoboriDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Kazuma SasakiDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Takahiro KanayaDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Yutaka IgarashiDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Ryuta NakaeDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Hidetaka OndaDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Tomohiko MasunoDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Satoshi SudaDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Kota SowaDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Masataka NakajimaDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Markus S SpurlockDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Lee Onn ChiengDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Tom G HazelNeuralstem, Inc., Germantown, MD, United States.
Karl JoheNeuralstem, Inc., Germantown, MD, United States.
Shyam GajavelliDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Akira FuseDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
M Ross BullockDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Hiroyuki YokotaDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
Nippon Medical School · JPUniversity of Miami · USNeural Signals (United States) · US

Funding

Olympus VS120 Fluorescence and Brightfield Slide Scanner for High-Throughput Image Acquisition at the University of MiamiS10OD023579 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MENDEZ, ARMANDO J · 2017 to 2017
$223k
6 · The paper itself

Abstract

Human neural stem cells (hNSCs) transplantation in several brain injury models has established their therapeutic potential. However, the feasibility of hNSCs transplantation is still not clear for acute subdural hematoma (ASDH) brain injury that needs external decompression. Thus, the aim of this pilot study was to test feasibility using a rat ASDH decompression model with two clinically relevant transplantation methods. Two different methods,

Indexed as

acute subdural hematomaneural stem celltransplantationtraumatic brain injurytreatment

Identifiers

PMID30809187
PMCPMC6379455
OpenAlexW2913610574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.