ArticleScientific reports2019
Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 82 citations in OpenAlex.
- A new chromosome-level genome assembly for western painted turtle Chrysemys picta bellii, a model for extreme physiological adaptations.BMC genomics · 2026Article
- Mitochondrial responses to anoxia-reoxygenation exposure in crucian carp (Carassius carassius).The Journal of experimental biology · 2026Article
- Metabolic changes during cardiac regeneration in the axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Low oxidative stress during mitochondrial recovery from anoxia in Artemia franciscana, an invertebrate extremophile.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Effects of hypoxia-reoxygenation on the bioenergetics and oxidative stress in the isolated mitochondria of the king scallop, Pecten maximus.The Journal of experimental biology · 2025Article
- Cold-induced fibrosis and metabolic remodeling in the turtle (Trachemys scripta) ventricle.Acta physiologica (Oxford, England) · 2025Article
- Metabolic stability of the Pallas' spadefoot Pelobates vespertinus under extreme hypoxia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Maintained mitochondrial integrity without oxygen in the anoxia-tolerant crucian carp.The Journal of experimental biology · 2024Article
- Sugar assimilation underlying dietary evolution of Neotropical bats.Nature ecology & evolution · 2024Article
- Hypoxia impairs blood glucose homeostasis in naked mole-rat adult subordinates but not queens.The Journal of experimental biology · 2024Article
- Effects of hibernation on two important contractile tissues in tibetan frogs, Nanorana parkeri: a perspective from transcriptomics and metabolomics approaches.BMC genomics · 2024Article
- Low Glycolysis Is Neuroprotective during Anoxic Spreading Depolarization (SD) and Reoxygenation in Locusts.eNeuro · 2023Article
- Metabolomic Profiling Reveals Differences in Hypoxia Response between Far Eastern and Siberian Frogs.Animals : an open access journal from MDPI · 2023Article
- Preventing mitochondrial reverse electron transport as a strategy for cardioprotection.Basic research in cardiology · 2023Review
- The Brain at High Altitude: From Molecular Signaling to Cognitive Performance.International journal of molecular sciences · 2023Review
- Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts.The Journal of experimental biology · 2023Article
- Resilience and phenotypic plasticity of Arctic char (Conservation physiology · 2023Article
- Surviving without oxygen involves major tissue specific changes in the proteome of crucian carp (PeerJ · 2023Article
- Article
- New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.Acta physiologica (Oxford, England) · 2022Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
ATP depletion and succinate accumulation during ischemia lead to oxidative damage to mammalian organs upon reperfusion. In contrast, freshwater turtles survive weeks of anoxia at low temperatures without suffering from oxidative damage upon reoxygenation, but the mechanisms are unclear. To determine how turtles survive prolonged anoxia, we measured ~80 metabolites in hearts from cold-acclimated (5 °C) turtles exposed to 9 days anoxia and compared the results with those for normoxic turtles (25 °C) and mouse hearts exposed to 30 min of ischemia. In turtles, ATP and ADP decreased to new steady-state levels during fasting and cold-acclimation and further with anoxia, but disappeared within 30 min of ischemia in mouse hearts. High NADH/NAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.