ArticleScientific reports2019
Recording single- and multi-unit neuronal action potentials from the surface of the dorsal root ganglion.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
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- Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.Nature communications · 2024Article
- Comparative analysis of energy transfer mechanisms for neural implants.Frontiers in neuroscience · 2023Review
- Poly(3,4-ethylenedioxythiophene)-Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Decoding Bilateral Hindlimb Kinematics From Cat Spinal Signals Using Three-Dimensional Convolutional Neural Network.Frontiers in neuroscience · 2022Article
- Article
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- High-density neural recordings from feline sacral dorsal root ganglia with thin-film array.Journal of neural engineering · 2021Article
- Implantable, Programmable, and Wireless Device for Electrical Stimulation of the Dorsal Root Ganglion in Freely-Moving Rats: A Proof of Concept Study.Journal of pain research · 2021Article
- Host tissue response to floating microelectrode arrays chronically implanted in the feline spinal nerve.Journal of neural engineering · 2020Article
- Spatial models of cell distribution in human lumbar dorsal root ganglia.The Journal of comparative neurology · 2020Article
- GCaMP as an indirect measure of electrical activity in rat trigeminal ganglion neurons.Cell calcium · 2020Article
- An impedance matching algorithm for common-mode interference removal in vagus nerve recordings.Journal of neuroscience methods · 2020Article
- Selectivity of afferent microstimulation at the DRG using epineural and penetrating electrode arrays.Journal of neural engineering · 2019Article
- Calcium imaging for analgesic drug discovery.Neurobiology of pain (Cambridge, Mass.)Review
- Transcranial alternating current stimulation can disrupt or reestablish neural entrainment in parkinsonian motor cortex.Brain stimulationArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The dorsal root ganglia (DRG) contain cell bodies of primary afferent neurons, which are frequently studied by recording extracellularly with penetrating microelectrodes inserted into the DRG. We aimed to isolate single- and multi-unit activity from primary afferents in the lumbar DRG using non-penetrating electrode arrays and to characterize the relationship of that activity with limb position and movement. The left sixth and seventh lumbar DRG (L6-L7) were instrumented with penetrating and non-penetrating electrode arrays to record neural activity during passive hindlimb movement in 7 anesthetized cats. We found that the non-penetrating arrays could record both multi-unit and well-isolated single-unit activity from the surface of the DRG, although with smaller signal to noise ratios (SNRs) compared to penetrating electrodes. Across all recorded units, the median SNR was 1.1 for non-penetrating electrodes and 1.6 for penetrating electrodes. Although the non-penetrating arrays were not anchored to the DRG or surrounding tissues, the spike amplitudes did not change (<1% change from baseline spike amplitude) when the limb was moved passively over a limited range of motion (~20 degrees at the hip). Units of various sensory fiber types were recorded, with 20% of units identified as primary muscle spindles, 37% as secondary muscle spindles, and 24% as cutaneous afferents. Our study suggests that non-penetrating electrode arrays can record modulated single- and multi-unit neural activity of various sensory fiber types from the DRG surface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.